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    dpr18 defective proboscis extension response 18 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpr18provided by FlyBase
    Official Full Name
    defective proboscis extension response 18provided by FlyBase
    Primary source
    FLYBASE:FBgn0030723
    Locus tag
    Dmel_CG14948
    See related
    AllianceGenome:FB:FBgn0030723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14948; CT34788; Dmel\CG14948; Dpr-18; Dpr18
    Summary
    Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. Is expressed in embryonic brain; larval ventral nerve cord; and lateral cord glial cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dpr18 in Genome Data Viewer
    Location:
    14A6-14A7; 1-52 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16063738..16070304)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15957771..15964337)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Mucin 14A Neighboring gene uncharacterized protein Neighboring gene nipsnap Neighboring gene Transducer of ERBB2 Neighboring gene mir-4958 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons. Bornstein B, et al. EMBO J, 2021 Jun 15. PMID 33847376, Free PMC Article
    2. Defective proboscis extension response (DPR), a member of the Ig superfamily required for the gustatory response to salt. Nakamura M, et al. J Neurosci, 2002 May 1. PMID 11978823, Free PMC Article
    3. Neural immunoglobulin superfamily interaction networks. Zinn K, et al. Curr Opin Neurobiol, 2017 Aug. PMID 28558267, Free PMC Article
    4. Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons. Wang Y, et al. Development, 2022 May 15. PMID 35502740, Free PMC Article
    5. Computational Assessment of Protein-Protein Binding Specificity within a Family of Synaptic Surface Receptors. Nandigrami P, et al. J Phys Chem B, 2022 Oct 6. PMID 35787023

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in sensory perception of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    defective proboscis extension response 18
    Names
    CG14948-PA
    dpr18-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16063738..16070304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132874.2 → NP_573102.1  defective proboscis extension response 18 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573102.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXK1
      Related
      FBpp0073986
      Conserved Domains (3) summary
      smart00408
      Location:417 → 461
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:242 → 325
      IG_like; Immunoglobulin like
      cl11960
      Location:258 → 326
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXK1 Q9VXK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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