U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ns3 Nucleostemin 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31097, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ns3provided by FlyBase
    Official Full Name
    Nucleostemin 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0266284
    Locus tag
    Dmel_CG14788
    See related
    AllianceGenome:FB:FBgn0266284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A60; BACN32G11.5; CG14788; Dmel\CG14788; dmNuc3; dNS3; EG:BACN32G11.5; l(1)2Ad; l(1)BA11; l(1)G0431; ns3; NS3
    Summary
    Enables GTPase activity. Involved in regulation of insulin receptor signaling pathway and ribosomal subunit export from nucleus. Located in cytoplasm. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human LSG1 (large 60S subunit nuclear export GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ns3 in Genome Data Viewer
    Location:
    2A4-2A4; 1-0.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1461844..1464220, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1355877..1358253, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Leucine-rich pentatricopeptide repeat containing 2 Neighboring gene uncharacterized protein Neighboring gene O-fucosyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila. Hartl TA, et al. Genetics, 2013 May. PMID 23436180, Free PMC Article
    2. The Drosophila stubarista phenotype is associated with a dosage effect of the putative ribosome-associated protein D-p40 on spineless. Melnick MB, et al. Genetics, 1993 Oct. PMID 7916731, Free PMC Article
    3. Observations on the induction of position effect variegation of euchromatic genes in Drosophila melanogaster. Pokholkova GV, et al. Genetics, 1993 May. PMID 8514132, Free PMC Article
    4. A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Kaplan DD, et al. Genes Dev, 2008 Jul 15. PMID 18628395, Free PMC Article
    5. New Functional Motifs for the Targeted Localization of Proteins to the Nucleolus in Drosophila and Human Cells. Ogienko AA, et al. Int J Mol Sci, 2024 Jan 19. PMID 38279227, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear export ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    nucleostemin 3
    Names
    CG14788-PA
    CG14788-PB
    Ns3-PA
    Ns3-PB
    lethal (1) 2Ad
    lethal (1) G0431
    nucleostemin ortholog 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1461844..1464220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297850.1 → NP_001284779.1  nucleostemin 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W590
      UniProtKB/TrEMBL
      X2JA43
      Conserved Domains (4) summary
      PHA03395
      Location:270 → 312
      p10; fibrous body protein; Provisional
      cd01857
      Location:164 → 395
      HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:161 → 524
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      cl21455
      Location:313 → 357
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_130559.3 → NP_569915.1  nucleostemin 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569915.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W590
      UniProtKB/TrEMBL
      X2JA43
      Related
      FBpp0070284
      Conserved Domains (4) summary
      PHA03395
      Location:270 → 312
      p10; fibrous body protein; Provisional
      cd01857
      Location:164 → 395
      HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:161 → 524
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      cl21455
      Location:313 → 357
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W590.1 Q9W590
    X2JA43 X2JA43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools