Moe Moesin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Moeprovided by FlyBase
Official Full Name: Moesinprovided by FlyBase
Primary source: FLYBASE:FBgn0011661
Locus tag: Dmel_CG10701
See related: AllianceGenome:FB:FBgn0011661
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.155; anon-WO03040301.157; anon-WO03040301.159; anon-WO03040301.161; CG10701; D17; Dmel\CG10701; dMoe; Dmoe; DMoe; Emr1; EMR1; ERM; gma; GMA; l(1)G0067; l(1)G0323; l(1)G0404; l(1)G0415; moe; Moes; moesin; moesin/ezrin/radixin homolog mRNA; p-Moesin
Summary: Enables actin binding activity; microtubule binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cytoskeleton organization; neuron development; and open tracheal system development. Located in several cellular components, including chromosome; cleavage furrow; and mitotic spindle midzone. Is active in cytoplasmic side of apical plasma membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Colocalizes with actin filament and spindle. Is expressed in several structures, including abdominal tracheal metamere; epithelium; ganglia; glomerulus; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24 and immunodeficiency 50. Orthologous to human EZR (ezrin); MSN (moesin); and RDX (radixin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 8B4-8B6; 1-25 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8873012..8898332, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8767045..8792365, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nuclear activity of the actin-binding Moesin protein is necessary for gene expression in Drosophila.
Title: The nuclear activity of the actin-binding Moesin protein is necessary for gene expression in Drosophila.
Data yet indicate that Moe is not directly involved in the stabilization of adherens junctions, but instead it mainly acts to regulate the apical cell perimeter during pupal wing morphogenesis.
Title: Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium.
Moesin is a novel apical polarity protein that drives cortical remodeling of dividing neuroblasts, which is essential for polarity maintenance and initial establishment of cell size asymmetry.
Title: Moesin is involved in polarity maintenance and cortical remodeling during asymmetric cell division.
These results indicate a critical role for Moesin in both neuronal morphogenesis and long-term memory formation.
Title: The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila.
The distribution of Moesin in the nucleus suggests a function in transcription and the depletion of mRNA export factors Nup98 or its interacting partner, Rae1, leads to the nuclear accumulation of Moesin, suggesting that the nuclear function of the protein is linked to mRNA export
Title: The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export.
Data show that Moesin upregulation influences extra-centrosome behavior and robust bipolar spindle formation.
Title: Moesin is a major regulator of centrosome behavior in epithelial cells with extra centrosomes.
Btsz and Moesin guide luminal membrane morphogenesis through organizing actin.
Title: Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin.
The conserved C-terminal coiled-coil domain of Slik, which is necessary and sufficient for apical localization of the kinase in epithelial cells, is not required for Moesin phosphorylation but is critical for the growth-promoting function of Slik.
Title: Regulation of Catalytic and Non-catalytic Functions of the Drosophila Ste20 Kinase Slik by Activation Segment Phosphorylation.
Early endocytosis maintains normal steady-state levels of Crumbs, which recruits apical phosphorylated (active) Moesin, which in turn regulates seamless tube shape through modulation of cortical actin filaments.
Title: Seamless tube shape is constrained by endocytosis-dependent regulation of active Moesin.
Moesin interacts with an unusual RhoGAP, Conundrum (Conu), and recruits it to the cell cortex to negatively regulate RhoA activity.
Title: Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0399 (e-PCR)
- UniSTS:6227

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	NAS Non-traceable Author Statement more info	PubMed
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament-based process	NAS Non-traceable Author Statement more info	PubMed
involved_in anterior/posterior pattern specification	TAS Traceable Author Statement more info	PubMed
involved_in branching involved in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of apical/basal cell polarity	TAS Traceable Author Statement more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of polarity of larval imaginal disc epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye photoreceptor cell development	TAS Traceable Author Statement more info	PubMed
involved_in lumen formation, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule anchoring	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of an epithelium	TAS Traceable Author Statement more info	PubMed
involved_in oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm assembly	TAS Traceable Author Statement more info	PubMed
involved_in pole plasm protein localization	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to rhabdomere	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential in photoreceptor cell	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhabdomere membrane biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with actin filament	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytoplasmic side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with spindle	IDA Inferred from Direct Assay more info	PubMed
part_of subapical complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: moesin

Names: CG10701-PA; CG10701-PB; CG10701-PC; CG10701-PD; CG10701-PE; CG10701-PF; CG10701-PG; CG10701-PH; CG10701-PI; CG10701-PJ; CG10701-PK; CG10701-PL; CG10701-PM; Ezrin-Radixin-Moesin; Ezrin-moesin-radixin-1; Moe-PA; Moe-PB; Moe-PC; Moe-PD; Moe-PE; Moe-PF; Moe-PG; Moe-PH; Moe-PI; Moe-PJ; Moe-PK; Moe-PL; Moe-PM; Moesin-like; dmoesin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8873012..8898332 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272432.1 → NP_001259361.1 moesin, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259361.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QP54, M9PHG2

Conserved Domains (3) summary

smart00295
Location:8 → 216

B41; Band 4.1 homologues

cd13194
Location:210 → 306

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:341 → 584

ERM; Ezrin/radixin/moesin family
NM_206668.3 → NP_996391.1 moesin, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996391.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QP54

Conserved Domains (3) summary

smart00295
Location:8 → 207

B41; Band 4.1 homologues

cd13194
Location:201 → 297

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:332 → 575

ERM; Ezrin/radixin/moesin family
NM_080343.4 → NP_525082.2 moesin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525082.2

Status: REVIEWED

UniProtKB/TrEMBL

C9QP54

Related

FBpp0071212

Conserved Domains (3) summary

smart00295
Location:8 → 207

B41; Band 4.1 homologues

cd13194
Location:201 → 297

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:332 → 575

ERM; Ezrin/radixin/moesin family
NM_001258654.1 → NP_001245583.1 moesin, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245583.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAH9, C9QP54

Conserved Domains (6) summary

smart00295
Location:26 → 278

B41; Band 4.1 homologues

cd13194
Location:272 → 368

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:163 → 278

FERM_M; FERM central domain

pfam00769
Location:403 → 646

ERM; Ezrin/radixin/moesin family

pfam09379
Location:28 → 83

FERM_N; FERM N-terminal domain

cl23720
Location:387 → 493

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_206667.3 → NP_996390.1 moesin, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996390.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QP54

Conserved Domains (3) summary

smart00295
Location:8 → 207

B41; Band 4.1 homologues

cd13194
Location:201 → 297

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:332 → 575

ERM; Ezrin/radixin/moesin family
NM_206666.3 → NP_996389.1 moesin, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996389.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QP54

Conserved Domains (3) summary

smart00295
Location:8 → 207

B41; Band 4.1 homologues

cd13194
Location:201 → 297

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:332 → 575

ERM; Ezrin/radixin/moesin family
NM_206669.2 → NP_996392.1 moesin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996392.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QP54

Conserved Domains (3) summary

smart00295
Location:8 → 207

B41; Band 4.1 homologues

cd13194
Location:201 → 297

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:332 → 575

ERM; Ezrin/radixin/moesin family
NM_206665.3 → NP_996388.1 moesin, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996388.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QP54

Conserved Domains (3) summary

smart00295
Location:8 → 207

B41; Band 4.1 homologues

cd13194
Location:201 → 297

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:332 → 575

ERM; Ezrin/radixin/moesin family
NM_206664.3 → NP_996387.1 moesin, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996387.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V458, P46150, P91930, Q24053, Q24435, Q7KVS6, Q7KVS7, Q9W3B4, Q9W3B5, Q9W3B6, Q9W3B7

UniProtKB/TrEMBL

C9QP54, M9NG50

Conserved Domains (3) summary

smart00295
Location:8 → 207

B41; Band 4.1 homologues

cd13194
Location:201 → 297

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:332 → 578

ERM; Ezrin/radixin/moesin family
NM_001258655.1 → NP_001245584.1 moesin, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245584.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V458, P46150, P91930, Q24053, Q24435, Q7KVS6, Q7KVS7, Q9W3B4, Q9W3B5, Q9W3B6, Q9W3B7

UniProtKB/TrEMBL

C9QP54, M9NG50

Conserved Domains (3) summary

smart00295
Location:8 → 207

B41; Band 4.1 homologues

cd13194
Location:201 → 297

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:332 → 578

ERM; Ezrin/radixin/moesin family
NM_167168.4 → NP_727290.1 moesin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727290.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QP54

Related

FBpp0071213

Conserved Domains (7) summary

smart00295
Location:26 → 278

B41; Band 4.1 homologues

cd13194
Location:272 → 368

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:163 → 278

FERM_M; FERM central domain

pfam00769
Location:403 → 649

ERM; Ezrin/radixin/moesin family

pfam09379
Location:28 → 83

FERM_N; FERM N-terminal domain

cd16269
Location:464 → 477

GBP_C; coiled coil [structural motif]

cl20817
Location:375 → 497

GBP_C; Guanylate-binding protein, C-terminal domain
NM_167169.2 → NP_727291.1 moesin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727291.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QP54

Related

FBpp0071214

Conserved Domains (6) summary

smart00295
Location:17 → 269

B41; Band 4.1 homologues

cd13194
Location:263 → 359

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:154 → 269

FERM_M; FERM central domain

pfam00769
Location:394 → 640

ERM; Ezrin/radixin/moesin family

pfam09379
Location:19 → 74

FERM_N; FERM N-terminal domain

cl23720
Location:378 → 484

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_167170.2 → NP_727292.1 moesin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727292.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P46150

Related

FBpp0071215

Conserved Domains (6) summary

smart00295
Location:1 → 141

B41; Band 4.1 homologues

cd13194
Location:135 → 231

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:26 → 141

FERM_M; FERM central domain

pfam00769
Location:266 → 512

ERM; Ezrin/radixin/moesin family

cd16269
Location:327 → 340

GBP_C; coiled coil [structural motif]

cl20817
Location:238 → 360

GBP_C; Guanylate-binding protein, C-terminal domain