ND-18 NADH dehydrogenase (ubiquinone) 18 kDa subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ND-18provided by FlyBase
Official Full Name: NADH dehydrogenase (ubiquinone) 18 kDa subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0031021
Locus tag: Dmel_CG12203
See related: AllianceGenome:FB:FBgn0031021
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12203; Dmel\CG12203; dNDUFS4; IP11020p; NDUFS4; NUYM; Q9VWI0
Summary: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19492421..19493337)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19386454..19387370)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IC Inferred by Curator more info	PubMed
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IC Inferred by Curator more info	PubMed
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

Names: CG12203-PA; FBpp0074481; NADH ubiquinone oxidoreductase 18 kDa; NADH-ubiquinone oxidoreductase 18 kDa subunit; NADH:ubiquinone oxidoreductase 18 kDa subunit; ND-18-PA

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The following sections contain reference sequences that belong to a specific genome build. Explain