Nup93-1 Nucleoporin 93kD-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nup93-1provided by FlyBase
Official Full Name: Nucleoporin 93kD-1provided by FlyBase
Primary source: FLYBASE:FBgn0027537
Locus tag: Dmel_CG11092
See related: AllianceGenome:FB:FBgn0027537
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD21129; CG11092; Dmel\CG11092; nup93; Nup93; nup93-1
Summary: Enables chromatin DNA binding activity. Involved in several processes, including oocyte karyosome formation; protein localization to nucleus; and regulation of nucleus size. Located in nuclear periphery. Part of nuclear pore. Is expressed in adult head; embryonic/larval midgut; and organism. Used to study nephrotic syndrome type 12. Human ortholog(s) of this gene implicated in nephrotic syndrome type 12. Orthologous to human NUP93 (nucleoporin 93). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13822826..13825910)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13716859..13719943)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
NOT involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome attachment to the nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear pore organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in oocyte karyosome formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nuclear inner membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nucleus size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore nuclear basket	ISS Inferred from Sequence or Structural Similarity more info