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    MtnC Metallothionein C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42416, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MtnCprovided by FlyBase
    Official Full Name
    Metallothionein Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038790
    Locus tag
    Dmel_CG5097
    See related
    AllianceGenome:FB:FBgn0038790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5097; Dmel\CG5097; MT; MTNC
    Summary
    Enables metal ion binding activity. Involved in cellular detoxification of metal ion and response to metal ion. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MtnC in Genome Data Viewer
    Location:
    92E4-92E4; 3-68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20360308..20360634)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16186030..16186356)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 92a Neighboring gene long non-coding RNA:CR45023 Neighboring gene Glial cell line-derived neurotrophic family receptor-like Neighboring gene eukaryotic translation initiation factor 3 subunit g2 Neighboring gene Trimethyllysine hydroxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chronic lead (Pb) exposure results in diminished hemocyte count and increased susceptibility to bacterial infection in Drosophila melanogaster. Nanda KP, et al. Chemosphere, 2019 Dec. PMID 31326753
    2. Is MtnE, the fifth Drosophila metallothionein, functionally distinct from the other members of this polymorphic protein family? Pérez-Rafael S, et al. Metallomics, 2012 Apr. PMID 22370740
    3. An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster. Catalán A, et al. PLoS Genet, 2016 Apr. PMID 27120580, Free PMC Article
    4. Dissection of Drosophila MTF-1 reveals a domain for differential target gene activation upon copper overload vs. copper starvation. Günther V, et al. Int J Biochem Cell Biol, 2012 Feb. PMID 22138226
    5. Metallothioneins and resistance to cadmium poisoning in Drosophila cells. Debec A, et al. Biochem Biophys Res Commun, 1985 Feb 28. PMID 3919723

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular detoxification of metal ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to metal ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to metal ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    metallothionein C
    Names
    CG5097-PA
    MtnC-PA
    metallothionein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20360308..20360634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142625.2 → NP_650882.1  metallothionein C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650882.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDN2
      UniProtKB/TrEMBL
      A0A1B3Q3M0
      Related
      FBpp0083292
      Conserved Domains (1) summary
      pfam02067
      Location:1 → 41
      Metallothio_5; Metallothionein family 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDN2.1 Q9VDN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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