U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Bsg Basigin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318841, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Bsgprovided by FlyBase
    Official Full Name
    Basiginprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261822
    Locus tag
    Dmel_CG31605
    See related
    AllianceGenome:FB:FBgn0261822
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    135/10; basigin; BcDNA:GH21853; bsg; BSG; CG31605; Dmel\CG31605; gel; l(2)06243; l(2)k06338; l(2)k09030; l(2)k13638; l(2)k14308; l(2)SH1217; l(2)SH2 1217; ms(2)08318; NP6293
    Summary
    Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including endoplasmic reticulum localization; photoreceptor cell morphogenesis; and sarcomere organization. Located in cytoskeleton of presynaptic active zone. Is expressed in several structures, including CNS surface glial cell; embryonic/larval midgut primordium; enterocyte of middle adult midgut epithelium; epithelium; and synaptic neuropil domain. Orthologous to several human genes including BSG (basigin (Ok blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Bsg in Genome Data Viewer
    Location:
    28E3-28E6; 2-30 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8083420..8116531)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8083420..8116531)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene TBP-related factor Neighboring gene Macroglobulin complement-related Neighboring gene antisense RNA:CR45257 Neighboring gene monensin sensitivity 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutational analysis of Drosophila basigin function in the visual system. Munro M, et al. Gene, 2010 Jan 1. PMID 19782733, Free PMC Article
    2. The origin and evolution of Basigin(BSG) gene: A comparative genomic and phylogenetic analysis. Zhu X, et al. Dev Comp Immunol, 2017 Jul. PMID 28223252
    3. Sphingolipids regulate neuromuscular synapse structure and function in Drosophila. West RJH, et al. J Comp Neurol, 2018 Sep 1. PMID 29761896, Free PMC Article
    4. Basigin/EMMPRIN/CD147 mediates neuron-glia interactions in the optic lamina of Drosophila. Curtin KD, et al. Glia, 2007 Nov 15. PMID 17729283
    5. Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. Curtin KD, et al. J Cell Sci, 2005 Jun 15. PMID 15928045

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Basigin Associates with Integrin in Order to Regulate Perineurial Glia and Drosophila Nervous System Morphology.
      Title: Basigin Associates with Integrin in Order to Regulate Perineurial Glia and Drosophila Nervous System Morphology.
    2. results suggest that the highly conserved transmembrane domain and the extracellular domains are crucial for basigin function in the visual system while the short intracellular tail may not play a role in these functions
      Title: Mutational analysis of Drosophila basigin function in the visual system.
    3. Basigin expression in photoreceptor neurons is required for normal structure and placement of glia cells
      Title: Basigin/EMMPRIN/CD147 mediates neuron-glia interactions in the optic lamina of Drosophila.
    4. Basigin promotes cytoskeletal rearrangements and the formation of lamellipodia in cultured insect cells
      Title: Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture.
    5. Bsg has a role regulating synaptic compartmentalization and strength, and coordinating plasma membrane and cortical organization.
      Title: The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton of presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic active zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    basigin
    Names
    Bsg-PA
    Bsg-PB
    Bsg-PC
    Bsg-PD
    Bsg-PE
    Bsg-PF
    Bsg-PG
    Bsg-PH
    Bsg-PI
    Bsg-PJ
    CG31605-PA
    CG31605-PB
    CG31605-PC
    CG31605-PD
    CG31605-PE
    CG31605-PF
    CG31605-PG
    CG31605-PH
    CG31605-PI
    CG31605-PJ
    D-basigin
    gelded
    lethal (2) SH1217

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8083420..8116531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164785.2 → NP_723341.1  basigin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723341.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPG9
      Related
      FBpp0079190
      Conserved Domains (3) summary
      smart00410
      Location:125 → 208
      IG_like; Immunoglobulin like
      pfam00047
      Location:124 → 199
      ig; Immunoglobulin domain
      cl11960
      Location:46 → 105
      Ig; Immunoglobulin domain

    2. NM_164784.2 → NP_723340.1  basigin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPG9
      Related
      FBpp0079191
      Conserved Domains (3) summary
      smart00410
      Location:125 → 208
      IG_like; Immunoglobulin like
      pfam00047
      Location:124 → 199
      ig; Immunoglobulin domain
      cl11960
      Location:46 → 105
      Ig; Immunoglobulin domain

    3. NM_164782.2 → NP_723338.1  basigin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723338.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPG9
      Related
      FBpp0079189
      Conserved Domains (3) summary
      smart00410
      Location:125 → 208
      IG_like; Immunoglobulin like
      pfam00047
      Location:124 → 199
      ig; Immunoglobulin domain
      cl11960
      Location:46 → 105
      Ig; Immunoglobulin domain

    4. NM_164783.2 → NP_723339.1  basigin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPG9
      Related
      FBpp0079188
      Conserved Domains (3) summary
      smart00410
      Location:125 → 208
      IG_like; Immunoglobulin like
      pfam00047
      Location:124 → 199
      ig; Immunoglobulin domain
      cl11960
      Location:46 → 105
      Ig; Immunoglobulin domain

    5. NM_164790.3 → NP_723346.2  basigin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723346.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTJ7
      Conserved Domains (3) summary
      cd00096
      Location:512 → 575
      Ig; Immunoglobulin domain
      smart00410
      Location:500 → 583
      IG_like; Immunoglobulin like
      cl11960
      Location:423 → 497
      Ig; Immunoglobulin domain

    6. NM_164787.2 → NP_723343.1  basigin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723343.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPG9
      Related
      FBpp0079193
      Conserved Domains (3) summary
      smart00410
      Location:125 → 208
      IG_like; Immunoglobulin like
      pfam00047
      Location:124 → 199
      ig; Immunoglobulin domain
      cl11960
      Location:46 → 105
      Ig; Immunoglobulin domain

    7. NM_001273295.1 → NP_001260224.1  basigin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260224.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCW5
      Conserved Domains (3) summary
      smart00410
      Location:125 → 208
      IG_like; Immunoglobulin like
      pfam00047
      Location:124 → 199
      ig; Immunoglobulin domain
      cl11960
      Location:46 → 105
      Ig; Immunoglobulin domain

    8. NM_164788.2 → NP_723344.1  basigin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723344.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPG9
      Related
      FBpp0079194
      Conserved Domains (3) summary
      smart00410
      Location:125 → 208
      IG_like; Immunoglobulin like
      pfam00047
      Location:124 → 199
      ig; Immunoglobulin domain
      cl11960
      Location:46 → 105
      Ig; Immunoglobulin domain

    9. NM_164786.2 → NP_723342.1  basigin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPG9
      Related
      FBpp0079192
      Conserved Domains (3) summary
      smart00410
      Location:125 → 208
      IG_like; Immunoglobulin like
      pfam00047
      Location:124 → 199
      ig; Immunoglobulin domain
      cl11960
      Location:46 → 105
      Ig; Immunoglobulin domain

    10. NM_164789.3 → NP_723345.1  basigin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPG9
      Related
      FBpp0079195
      Conserved Domains (3) summary
      smart00410
      Location:125 → 208
      IG_like; Immunoglobulin like
      pfam00047
      Location:124 → 199
      ig; Immunoglobulin domain
      cl11960
      Location:46 → 105
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCW5 M9PCW5
    Q7KTJ7 Q7KTJ7
    Q8IPG9 Q8IPG9
    Q961I4 Q961I4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous