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    CG12917 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36065, updated on 17-Dec-2024

    Summary

    Official Symbol
    CG12917provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033490
    Locus tag
    Dmel_CG12917
    See related
    AllianceGenome:FB:FBgn0033490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12917
    Summary
    Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CG12917 in Genome Data Viewer
    Location:
    46F2-46F2; 2-62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10137656..10139267)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6025161..6026772)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Copper chaperone for superoxide dismutase Neighboring gene gemini Neighboring gene antisense RNA:CR43467 Neighboring gene Odorant receptor 46a Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45133 Neighboring gene KCNQ potassium channel

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity  
    enables hydrolase activity  
    enables metal ion binding  
    enables nucleic acid binding  
    enables single-stranded DNA endodeoxyribonuclease activity  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane  
    is_active_in nucleus  

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG12917-PB
    NP_610558.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10137656..10139267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136714.3 → NP_610558.2  uncharacterized protein Dmel_CG12917 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610558.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z853, Q4V3G1, Q4V3M5
      Conserved Domains (1) summary
      smart00892
      Location:129 → 353
      Endonuclease_NS; DNA/RNA non-specific endonuclease
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