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    P5CDh1 delta-1-Pyrroline-5-carboxylate dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    P5CDh1provided by FlyBase
    Official Full Name
    delta-1-Pyrroline-5-carboxylate dehydrogenase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037138
    Locus tag
    Dmel_CG7145
    See related
    AllianceGenome:FB:FBgn0037138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7145; Dmel\CG7145; DmP5CDh1; P5CDh
    Summary
    Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Involved in proline metabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Used to study hyperprolinemia type 2. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See P5CDh1 in Genome Data Viewer
    Location:
    78F4-78F4; 3-47 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21836665..21841356, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21829765..21834456, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Nopp140 Neighboring gene transfer RNA:Cysteine-GCA 4-1 Neighboring gene uncharacterized protein Neighboring gene mushroom-body expressed

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequences, phylogeny and evolution of mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenases (ALDH4A1). Evidence for a second locus (ALDH4A2) in Drosophila. Holmes RS. Chem Biol Interact, 2023 Sep 25. PMID 37597643
    2. Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity-Establishing a fly model for human type II hyperprolinemia. He F, et al. Mitochondrion, 2011 May. PMID 21168532
    3. Deletion of Drosophila Nopp140 induces subcellular ribosomopathies. He F, et al. Chromosoma, 2015 Jun. PMID 25384888
    4. Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study. Cuesta-Astroz Y, et al. Front Genet, 2021. PMID 34394179, Free PMC Article
    5. The quantitative genetic basis of male mating behavior in Drosophila melanogaster. Moehring AJ, et al. Genetics, 2004 Jul. PMID 15280239, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Homozygous (CG7145(f04633)/CG7145(f04633)) individuals displayed proline levels twice that of normal, swollen mitochondria, and ultimately larval and pupal lethality.
      Title: Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity-Establishing a fly model for human type II hyperprolinemia.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proline catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proline catabolic process to glutamate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    delta-1-Pyrroline-5-carboxylate dehydrogenase 1
    Names
    CG7145-PA
    CG7145-PB
    CG7145-PD
    CG7145-PE
    CG7145-PF
    P5CDh1-PA
    P5CDh1-PB
    P5CDh1-PD
    P5CDh1-PE
    P5CDh1-PF
    delta-1-pyrroline-5-carboxylate dehydrogenase
    NP_001189159.1
    NP_001262196.1
    NP_649368.2
    NP_730695.1
    NP_730698.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21836665..21841356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168945.5 → NP_730698.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730698.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3P0, Q9VNX4
      Related
      FBpp0078101
      Conserved Domains (1) summary
      cd07123
      Location:41 → 563
      ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17

    2. NM_168942.5 → NP_730695.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3P0, Q9VNX4
      Related
      FBpp0078099
      Conserved Domains (1) summary
      cd07123
      Location:41 → 563
      ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17

    3. NM_001275267.1 → NP_001262196.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3P0, Q9VNX4
      Conserved Domains (1) summary
      cd07123
      Location:41 → 563
      ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17

    4. NM_001202230.2 → NP_001189159.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189159.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3P0, Q9VNX4
      Conserved Domains (1) summary
      cd07123
      Location:41 → 563
      ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17

    5. NM_141111.6 → NP_649368.2  delta-1-Pyrroline-5-carboxylate dehydrogenase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649368.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3P0, Q9VNX4
      Related
      FBpp0078100
      Conserved Domains (1) summary
      cd07123
      Location:41 → 563
      ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T3P0 Q8T3P0
    Q9VNX4 Q9VNX4

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