Mtnr1a melatonin receptor 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtnr1aprovided by RGD
Official Full Name: melatonin receptor 1Aprovided by RGD
Primary source: RGD:620797
See related: EnsemblRapid:ENSRNOG00000028744 AllianceGenome:RGD:620797
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hormone binding activity; melatonin receptor activity; and organic cyclic compound binding activity. Involved in camera-type eye development; circadian rhythm; and negative regulation of insulin secretion. Located in neuronal cell body. Biomarker of type 2 diabetes mellitus. Orthologous to human MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 4.2), Adrenal (RPKM 1.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 16q11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (53876964..53896421, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (47144461..47163919, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (50339358..50358809, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We demonstrated the co-existence of MT1 and MT2 receptors in all melanopsin-positive M1 ipRGCs, and the expression of MT1 and MT2 receptors in these cells could be seen as early as the day of birth (P0).
Title: Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells.
The present study demonstrates, for the first time, that MT1a receptors are localized and expressed in rat vestibular nuclei. This study provides additional insight into the role of melatonin receptors during vestibular signal processing.
Title: Immunohistochemical and biomolecular identification of melatonin 1a and 1b receptors in rat vestibular nuclei.
Expression and high amplitude diurnal variation of functional MT1 melatonin receptors is indicated in the rat adrenal gland.
Title: Rhythmic expression of functional MT1 melatonin receptors in the rat adrenal gland.
MT1 might play an important role in the pathogenesis of acute necrotizing pancreatitis. Expression was down-regulated as the severity of the disease increased.
Title: [The expression of melatonin MT1 receptor in acute necrotizing pancreatitis rats and the protective effects of melatonin].
Data indicate that fetal adrenal gland showed circadian expression of Bmal-1 and Per-2 as well as of Mt1 and Egr-1.
Title: A circadian clock entrained by melatonin is ticking in the rat fetal adrenal.
We report for the first time, an age-related reduction in mRNA MT1 and MT2 expression levels as well as MT1 protein expression in all tissues tested except the thymus.
Title: Decreased MT1 and MT2 melatonin receptor expression in extrapineal tissues of the rat during physiological aging.
N-nitroso-N-methylurea disrupted and dietary methylselenocysteine significantly increased the expression of MTNR1A in mammary glands of Fischer 344 rats
Title: Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo.
MT1 is highly expressed in the hypothalamus, lung, kidney, adrenal gland, stomach, and ovary, while MT2 is highly expressed in the hippocampus, kidney, and ovary
Title: Gene structures, biochemical characterization and distribution of rat melatonin receptors.
The rat melatonin receptor 1A (melatonin MT1 receptor)was cloned and the binding affinity for different compounds was compared with the human counterpart.
Title: Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors.
Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells
Title: Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone binding	IEA Inferred from Electronic Annotation more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables melatonin receptor activity	IEA Inferred from Electronic Annotation more info
enables melatonin receptor activity	ISO Inferred from Sequence Orthology more info
enables organic cyclic compound binding	IEA Inferred from Electronic Annotation more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melatonin receptor type 1A

Names: mel-1A-R; mel1a melatonin receptor; mel1a receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.