Klhl22 kelch-like family member 22 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhl22provided by RGD
Official Full Name: kelch-like family member 22provided by RGD
Primary source: RGD:1306288
See related: EnsemblRapid:ENSRNOG00000001878 AllianceGenome:RGD:1306288
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306288
Summary: Predicted to enable 14-3-3 protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including cellular response to L-leucine; mitotic spindle assembly checkpoint signaling; and negative regulation of metabolic process. Predicted to be located in centrosome; intercellular bridge; and lysosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol; mitotic spindle; and polar microtubule. Predicted to colocalize with nucleus. Orthologous to human KLHL22 (kelch like family member 22). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 120.8), Brain (RPKM 108.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (96695168..96736079, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (83190891..83231746, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (87646489..87718808)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131807 (e-PCR)
- UniSTS:215090

RH138822 (e-PCR)
- UniSTS:220909

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell division	ISO Inferred from Sequence Orthology more info
involved_in cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to L-leucine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-leucine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated immune response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein monoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein monoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in polar microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in polar microtubule	ISO Inferred from Sequence Orthology more info
located_in polar microtubule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kelch-like protein 22

Names: kelch-like 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107079.1 → NP_001100549.1 kelch-like protein 22

See identical proteins and their annotated locations for NP_001100549.1

Status: PROVISIONAL

Source sequence(s)

CH473999

UniProtKB/Swiss-Prot

D3ZZC3, D4A9W5

UniProtKB/TrEMBL

A0A0G2KA06

Related

ENSRNOP00000112391.1, ENSRNOT00000166570.1

Conserved Domains (4) summary

PHA03098
Location:52 → 592

PHA03098; kelch-like protein; Provisional

sd00038
Location:340 → 385

Kelch; KELCH repeat [structural motif]

cd18461
Location:147 → 250

BACK_KLHL22; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22)

cl38908
Location:27 → 151

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

96695168..96736079 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270457.1 → XP_063126527.1 kelch-like protein 22 isoform X3

UniProtKB/TrEMBL

A0A0G2KA06
XM_006248700.5 → XP_006248762.1 kelch-like protein 22 isoform X2

UniProtKB/TrEMBL

A0A0G2KA06

Conserved Domains (6) summary

smart00612
Location:631 → 677

Kelch; Kelch domain

smart00875
Location:239 → 342

BACK; BTB And C-terminal Kelch

PHA03098
Location:138 → 678

PHA03098; kelch-like protein; Provisional

sd00038
Location:426 → 471

Kelch; KELCH repeat [structural motif]

pfam00651
Location:131 → 229

BTB; BTB/POZ domain

pfam01344
Location:476 → 519

Kelch_1; Kelch motif
XM_006248699.5 → XP_006248761.1 kelch-like protein 22 isoform X1

UniProtKB/TrEMBL

A0A0G2KA06, A0A8L2QUL2

Related

ENSRNOP00000063573.2, ENSRNOT00000068711.4

Conserved Domains (6) summary

smart00612
Location:631 → 677

Kelch; Kelch domain

smart00875
Location:239 → 342

BACK; BTB And C-terminal Kelch

PHA03098
Location:138 → 678

PHA03098; kelch-like protein; Provisional

sd00038
Location:426 → 471

Kelch; KELCH repeat [structural motif]

pfam00651
Location:131 → 229

BTB; BTB/POZ domain

pfam01344
Location:476 → 519

Kelch_1; Kelch motif
XM_063270458.1 → XP_063126528.1 kelch-like protein 22 isoform X4