SAR1 synaptobrevin-related protein 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SAR1
Official Full Name: synaptobrevin-related protein 1
Primary source: TAIR:AT2G33120
Locus tag: AT2G33120
See related: Araport:AT2G33120
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA VESICLE-ASSOCIATED MEMBRANE PROTEIN 722; ATVAMP722; F25I18.14; F25I18_14; synaptobrevin-related protein 1; VAMP722
Summary: Encodes a member of Synaptobrevin-like protein family. Also known as VESICLE-ASSOCIATED MEMBRANE PROTEIN 722 (VAMP722). Required for cell plate formation.
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Genomic context

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See SAR1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 5

Sequence:: Chromosome: 2; NC_003071.7 (14043400..14045695, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNARE proteins VAMP721 and VAMP722 mediate the post-Golgi trafficking required for auxin-mediated development in Arabidopsis.
Title: SNARE proteins VAMP721 and VAMP722 mediate the post-Golgi trafficking required for auxin-mediated development in Arabidopsis.
CCOAOMT1, a candidate cargo secreted via VAMP721/722 secretory vesicles in Arabidopsis.
Title: CCOAOMT1, a candidate cargo secreted via VAMP721/722 secretory vesicles in Arabidopsis.
Endoplasmic reticulum stress and immune signalings distinctly control cellular abundance of VAMP721/722.
Title: Regulation of cellular VAMP721/722 abundance in arabidopsis.
Sar1 and Sec23 interact in the process of endoplasmic reticulum protein export.
Title: Using Homology Modeling to Understand the Structural Basis of Specific Interaction of a Plant-Specific AtSar1a-AtSec23a Pair Involved in Protein ER Export.
RPW8.2 is initially carried on VAMP721/722 vesicles, and that VAMP721, and to a much lesser extent VAMP722, are essential for transporting RPW8.2 to the extrahaustorial membrane and for the defense activity of RPW8.2.
Title: The powdery mildew resistance protein RPW8.2 is carried on VAMP721/722 vesicles to the extrahaustorial membrane of haustorial complexes.
The expression of VAMP721/722 genes whose products drive secretory vesicles to the target plasma membrane, was analyzed.
Title: Model for regulation of VAMP721/722-mediated secretion: growth vs. stress responses.
This suggests that the plant growth/immunity-involved VAMP721/722 form SNARE complexes with multiple plasma membrane syntaxins to discharge cue-dependent cargo molecules.
Title: Requirement of vesicle-associated membrane protein 721 and 722 for sustained growth during immune responses in Arabidopsis.
These observations suggest that VAMP721 and VAMP722 are involved in secretory trafficking to the plasma membrane via trans-Golgi network/early endosomal compartment.
Title: Arabidopsis R-SNARE proteins VAMP721 and VAMP722 are required for cell plate formation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001036392.1

Supported by ESTs:

NM_001202735.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell plate formation involved in plant-type cell wall biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	IPI Inferred from Physical Interaction more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell plate	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	TAS Traceable Author Statement more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: synaptobrevin-related protein 1

NP_001031469.1

synaptobrevin-related protein 1 (SAR1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: transport, vesicle-mediated transport; LOCATED IN: endosome, plasma membrane, membrane; EXPRESSED IN: male gametophyte, cultured cell, pollen tube; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Longin (InterPro:IPR010908), Longin-like (InterPro:IPR011012), Synaptobrevin (InterPro:IPR001388); BEST Arabidopsis thaliana protein match is: vesicle-associated membrane protein 721 (TAIR:AT1G04750.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_001189664.1

synaptobrevin-related protein 1 (SAR1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: vesicle-mediated transport; LOCATED IN: endosome, plasma membrane, membrane; EXPRESSED IN: male gametophyte, pollen tube; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Synaptobrevin (InterPro:IPR001388); BEST Arabidopsis thaliana protein match is: vesicle-associated membrane protein 726 (TAIR:AT1G04760.1).

NP_180871.1

synaptobrevin-related protein 1 (SAR1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: transport, vesicle-mediated transport; LOCATED IN: endosome, plasma membrane, membrane; EXPRESSED IN: male gametophyte, cultured cell, pollen tube; EXPRESSED DURING: M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Longin (InterPro:IPR010908), Longin-like (InterPro:IPR011012), Synaptobrevin (InterPro:IPR001388); BEST Arabidopsis thaliana protein match is: vesicle-associated membrane protein 721 (TAIR:AT1G04750.1); Has 2435 Blast hits to 2434 proteins in 262 species: Archae - 0; Bacteria - 0; Metazoa - 970; Fungi - 440; Plants - 608; Viruses - 0; Other Eukaryotes - 417 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

14043400..14045695 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128872.3 → NP_180871.1 synaptobrevin-related protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180871.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O49321, P47192

UniProtKB/TrEMBL

A0A178VX95, A0A5S9X3J5, Q681H0

Conserved Domains (2) summary

cd14824
Location:7 → 121

Longin; longin domain

pfam00957
Location:127 → 195

Synaptobrevin
NM_001202735.1 → NP_001189664.1 synaptobrevin-related protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189664.1

Status: REVIEWED

UniProtKB/TrEMBL

F4IVQ2

Conserved Domains (2) summary

cd15843
Location:50 → 106

R-SNARE; SNARE motif, subgroup R-SNARE

pfam00957
Location:51 → 113

Synaptobrevin; Synaptobrevin
NM_001036392.1 → NP_001031469.1 synaptobrevin-related protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031469.1

Status: REVIEWED

UniProtKB/TrEMBL

B9DH97, Q681H0

Conserved Domains (3) summary

cd15843
Location:138 → 196

R-SNARE; SNARE motif, subgroup R-SNARE

pfam00957
Location:135 → 203

Synaptobrevin; Synaptobrevin

pfam13774
Location:32 → 111

Longin; Regulated-SNARE-like domain