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    PMEAMT S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841281, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PMEAMT
    Official Full Name
    S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
    Primary source
    TAIR:AT1G48600
    Locus tag
    AT1G48600
    See related
    Araport:AT1G48600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPMEAMT; phosphoethanolamine N-methyltransferase; T1N15.23; T1N15_23
    Summary
    Encodes a phosphoethanolamine N-methyltransferase that catalyses the last two methylation steps of the three sequential methylations of phosphoethanolamine (PEA) that are required for the synthesis of phosphocholine (PCho) in plants.
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    Genomic context

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    See PMEAMT in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (17965871..17969354)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene ncRNA Neighboring gene Flavoprotein Neighboring gene AT hook motif-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Methyltransferase Trio Essential for Phosphatidylcholine Biosynthesis and Growth. Liu YC, et al. Plant Physiol, 2019 Feb. PMID 30518673, Free PMC Article
    2. Identification of phosphomethylethanolamine N-methyltransferase from Arabidopsis and its role in choline and phospholipid metabolism. BeGora MD, et al. J Biol Chem, 2010 Sep 17. PMID 20650897, Free PMC Article
    3. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
    4. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PMT2 (or PMEAMT; At1g48600) has a critical role in phosphatidylcholine biosynthesis and growth.
      Title: A Methyltransferase Trio Essential for Phosphatidylcholine Biosynthesis and Growth.
    2. phosphomethylethanolamine N-methyltransferase is involved in Arabidopsis choline and phospholipid metabolism.
      Title: Identification of phosphomethylethanolamine N-methyltransferase from Arabidopsis and its role in choline and phospholipid metabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Miscellaneous features

    • Loc: 17965933-17966010 AT1G48600.uORF1
    NM_103756.3
    NM_202264.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoethanolamine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
    NP_175293.1
    • phosphoethanolamine N-methyltransferase (PMEAMT); FUNCTIONS IN: phosphomethylethanolamine N-methyltransferase activity, phosphoethanolamine N-methyltransferase activity; INVOLVED IN: phosphatidylcholine biosynthetic process; EXPRESSED IN: sperm cell, cotyledon, male gametophyte, guard cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: S-adenosyl-L-methionine-dependent methyltransferases superfamily protein (TAIR:AT3G18000.1); Has 21397 Blast hits to 20726 proteins in 2642 species: Archae - 625; Bacteria - 15762; Metazoa - 271; Fungi - 989; Plants - 576; Viruses - 5; Other Eukaryotes - 3169 (source: NCBI BLink).
    NP_973993.1
    • phosphoethanolamine N-methyltransferase (PMEAMT); FUNCTIONS IN: phosphomethylethanolamine N-methyltransferase activity, phosphoethanolamine N-methyltransferase activity; INVOLVED IN: phosphatidylcholine biosynthetic process; EXPRESSED IN: sperm cell, cotyledon, male gametophyte, guard cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: S-adenosyl-L-methionine-dependent methyltransferases superfamily protein (TAIR:AT3G18000.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17965871..17969354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202264.2 → NP_973993.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HYI6, Q944H0, Q9LP63, Q9LP64
      UniProtKB/TrEMBL
      A0A178WLJ9, A0A5S9WMS2
      Conserved Domains (1) summary
      PLN02336
      Location:17 → 491
      PLN02336; phosphoethanolamine N-methyltransferase

    2. NM_103756.3 → NP_175293.1  S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175293.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WLU9, A0A5S9WMS2
      Conserved Domains (1) summary
      PLN02336
      Location:1 → 475
      PLN02336; phosphoethanolamine N-methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q944H0.2

    Gene LinkOut

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