WES1 Auxin-responsive GH3 family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: WES1
Official Full Name: Auxin-responsive GH3 family protein
Primary source: TAIR:AT4G27260
Locus tag: AT4G27260
See related: Araport:AT4G27260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: GH3.5; M4I22.70; M4I22_70
Summary: encodes an IAA-amido synthase that conjugates Asp and other amino acids to auxin in vitro. Lines carrying insertions in this gene are hypersensitive to auxin. It is involved in camalexin biosynthesis via conjugating indole-3-carboxylic acid (ICA) and cysteine (Cys).
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Genomic context

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See WES1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 3

Sequence:: Chromosome: 4; NC_003075.7 (13653579..13656285)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study suggests that AtGH3.5 conjugates auxins (i.e., IAA and PAA) and benzoates (i.e., SA and BA) to mediate crosstalk between different metabolic pathways, broadening the potential roles for GH3 acyl acid amido synthetases in plants.
Title: Arabidopsis thaliana GH3.5 acyl acid amido synthetase mediates metabolic crosstalk in auxin and salicylic acid homeostasis.
Arabidopsis acetyl-amido synthetase GH3.5 involvement in camalexin biosynthesis through conjugation of indole-3-carboxylic acid and cysteine and upregulation of camalexin biosynthesis genes.
Title: Arabidopsis acetyl-amido synthetase GH3.5 involvement in camalexin biosynthesis through conjugation of indole-3-carboxylic acid and cysteine and upregulation of camalexin biosynthesis genes.
GH3.5 gene is required for fine-tuning adventitious root initiation in the Arabidopsis thaliana hypocotyl, and is acting by modulating jasmonic acid homeostasis
Title: Auxin controls Arabidopsis adventitious root initiation by regulating jasmonic acid homeostasis.
Results provide support for WES1 regulating hypocotyl growth by mediating phytochrome B-perceived light signals.
Title: An Arabidopsis GH3 gene, encoding an auxin-conjugating enzyme, mediates phytochrome B-regulated light signals in hypocotyl growth.
This study shows that GH3.5 acts as a bifunctional modulator in both salicylic acid and auxin signaling during pathogen infection.
Title: Dual regulation role of GH3.5 in salicylic acid and auxin signaling during Arabidopsis-Pseudomonas syringae interaction.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_118860.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables indole-3-acetic acid amido synthetase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within camalexin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular auxin homeostasis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of camalexin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auxin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Auxin-responsive GH3 family protein

NP_194456.1

WES1; CONTAINS InterPro DOMAIN/s: GH3 auxin-responsive promoter (InterPro:IPR004993); BEST Arabidopsis thaliana protein match is: Auxin-responsive GH3 family protein (TAIR:AT5G54510.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

13653579..13656285

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118860.5 → NP_194456.1 Auxin-responsive GH3 family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194456.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O81829

UniProtKB/TrEMBL

A0A178V256, A0A384KSP5, A0A5S9XWQ1, Q0GUM1

Conserved Domains (1) summary

PLN02620
Location:1 → 612

PLN02620; indole-3-acetic acid-amido synthetase