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    CYP708A2 cytochrome P450, family 708, subfamily A, polypeptide 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834851, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP708A2
    Official Full Name
    cytochrome P450, family 708, subfamily A, polypeptide 2
    Primary source
    TAIR:AT5G48000
    Locus tag
    AT5G48000
    See related
    Araport:AT5G48000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; CYP708 A2; cytochrome P450; CYTOCHROME P450; family 708; FAMILY 708; MDN11.7; MDN11_7; polypeptide 2; POLYPEPTIDE 2; polypeptide 2''; subfamily A; SUBFAMILY A; THAH; THAH1; THALIANOL HYDROXYLASE; THALIANOL HYDROXYLASE 1
    Summary
    Encodes a member of the CYP708A family of cytochrome P450 enzymes. THAH appears to add a hydroxyl group to the triterpene thalianol. thah1 mutants have an elevated accumulation of thalianol. thah1-1 mutants have longer roots than wild type plants. Thalian-diol and desaturated thalian-diol are lost from the root extracts of thah1-1 mutants. Overexpression of the sequence from At5g48000.1 rescues the thah1-1 mutant phenotype (Field 2008); it is unknown whether the shorter sequences associated with other gene models would provide functional complementation.
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    Genomic context

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    See CYP708A2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (19444103..19447866, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 5 Neighboring gene thalianol synthase 1 Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolic diversification--independent assembly of operon-like gene clusters in different plants. Field B, et al. Science, 2008 Apr 25. PMID 18356490
    2. Formation of plant metabolic gene clusters within dynamic chromosomal regions. Field B, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21876149, Free PMC Article
    3. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
    5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036953.1
    NM_001085263.2
    NM_001344755.1
    NM_001344756.1
    NM_124174.3
    NM_180821.3
    NM_180822.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thalianol hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thalianol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    cytochrome P450, family 708, subfamily A, polypeptide 2
    NP_001032030.1
    • ''cytochrome P450, family 708, subfamily A, polypeptide 2'' (CYP708A2); FUNCTIONS IN: thalianol hydroxylase activity, oxygen binding; INVOLVED IN: thalianol metabolic process, root development; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: hypocotyl, root, callus; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 708, subfamily A, polypeptide 3 (TAIR:AT1G78490.1); Has 28669 Blast hits to 28599 proteins in 1593 species: Archae - 49; Bacteria - 4977; Metazoa - 10233; Fungi - 5005; Plants - 7168; Viruses - 6; Other Eukaryotes - 1231 (source: NCBI BLink).
    NP_001078732.1
    • ''cytochrome P450, family 708, subfamily A, polypeptide 2'' (CYP708A2); CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 708, subfamily A, polypeptide 3 (TAIR:AT1G78490.1); Has 28655 Blast hits to 28585 proteins in 1591 species: Archae - 49; Bacteria - 4965; Metazoa - 10231; Fungi - 5005; Plants - 7168; Viruses - 6; Other Eukaryotes - 1231 (source: NCBI BLink).
    NP_001318756.1
    • ''cytochrome P450, family 708, subfamily A, polypeptide 2'' (CYP708A2); FUNCTIONS IN: thalianol hydroxylase activity, oxygen binding; INVOLVED IN: thalianol metabolic process, root development; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: hypocotyl, root, callus; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 708, subfamily A, polypeptide 3 (TAIR:AT1G78490.1); Has 28655 Blast hits to 28585 proteins in 1591 species: Archae - 49; Bacteria - 4965; Metazoa - 10231; Fungi - 5005; Plants - 7168; Viruses - 6; Other Eukaryotes - 1231 (source: NCBI BLink).
    NP_851152.1
    • ''cytochrome P450, family 708, subfamily A, polypeptide 2'' (CYP708A2); FUNCTIONS IN: thalianol hydroxylase activity, oxygen binding; INVOLVED IN: thalianol metabolic process, root development; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: hypocotyl, root, callus; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 708, subfamily A, polypeptide 3 (TAIR:AT1G78490.1); Has 28765 Blast hits to 28695 proteins in 1599 species: Archae - 49; Bacteria - 5026; Metazoa - 10250; Fungi - 5008; Plants - 7191; Viruses - 6; Other Eukaryotes - 1235 (source: NCBI BLink).
    NP_851153.1
    • ''cytochrome P450, family 708, subfamily A, polypeptide 2'' (CYP708A2); FUNCTIONS IN: thalianol hydroxylase activity, oxygen binding; INVOLVED IN: thalianol metabolic process, root development; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: hypocotyl, root, callus; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 708, subfamily A, polypeptide 3 (TAIR:AT1G78490.1); Has 28655 Blast hits to 28585 proteins in 1591 species: Archae - 49; Bacteria - 4965; Metazoa - 10231; Fungi - 5005; Plants - 7168; Viruses - 6; Other Eukaryotes - 1231 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19444103..19447866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344755.1 → NP_001318756.1  cytochrome P450, family 708, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGZ3, Q3E8E7, Q3E8E8, Q8L7D5, Q9FI38
      UniProtKB/TrEMBL
      A0A178U980, A0A654G902
      Conserved Domains (1) summary
      cd11043
      Location:67 → 474
      CYP90-like; plant cytochrome P450s similar to cytochrome P450 family 90, subfamily A, polypeptide 1, cytochrome P450 family 90, subfamily B, polypeptide 1, and cytochrome P450 family 90, subfamily D, polypeptide 2

    2. NM_001085263.2 → NP_001078732.1  cytochrome P450, family 708, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078732.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGZ3, Q3E8E7, Q3E8E8, Q8L7D5, Q9FI38
      UniProtKB/TrEMBL
      A0A178U980, A0A654G902
      Conserved Domains (1) summary
      cd11043
      Location:67 → 474
      CYP90-like; plant cytochrome P450s similar to cytochrome P450 family 90, subfamily A, polypeptide 1, cytochrome P450 family 90, subfamily B, polypeptide 1, and cytochrome P450 family 90, subfamily D, polypeptide 2

    3. NM_180821.3 → NP_851152.1  cytochrome P450, family 708, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851152.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G902, F4K051
      Conserved Domains (1) summary
      cl12078
      Location:64 → 516
      p450; Cytochrome P450

    4. NM_001344756.1 → NP_001330320.1  cytochrome P450, family 708, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGZ3, Q3E8E7, Q3E8E8, Q8L7D5, Q9FI38
      UniProtKB/TrEMBL
      A0A178U980, A0A654G902
      Conserved Domains (1) summary
      cd11043
      Location:67 → 474
      CYP90-like; plant cytochrome P450s similar to cytochrome P450 family 90, subfamily A, polypeptide 1, cytochrome P450 family 90, subfamily B, polypeptide 1, and cytochrome P450 family 90, subfamily D, polypeptide 2

    5. NM_180822.2 → NP_851153.1  cytochrome P450, family 708, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851153.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGZ3, Q3E8E7, Q3E8E8, Q8L7D5, Q9FI38
      UniProtKB/TrEMBL
      A0A178U980, A0A654G902
      Conserved Domains (1) summary
      cd11043
      Location:67 → 474
      CYP90-like; plant cytochrome P450s similar to cytochrome P450 family 90, subfamily A, polypeptide 1, cytochrome P450 family 90, subfamily B, polypeptide 1, and cytochrome P450 family 90, subfamily D, polypeptide 2

    6. NM_001036953.1 → NP_001032030.1  cytochrome P450, family 708, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032030.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGZ3, Q3E8E7, Q3E8E8, Q8L7D5, Q9FI38
      UniProtKB/TrEMBL
      A0A178U980, A0A654G902
      Conserved Domains (1) summary
      cd11043
      Location:67 → 474
      CYP90-like; plant cytochrome P450s similar to cytochrome P450 family 90, subfamily A, polypeptide 1, cytochrome P450 family 90, subfamily B, polypeptide 1, and cytochrome P450 family 90, subfamily D, polypeptide 2

    7. NM_124174.3 → NP_199611.2  cytochrome P450, family 708, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199611.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGZ3, Q3E8E7, Q3E8E8, Q8L7D5, Q9FI38
      UniProtKB/TrEMBL
      A0A178U980, A0A654G902
      Conserved Domains (1) summary
      cd11043
      Location:67 → 474
      CYP90-like; plant cytochrome P450s similar to cytochrome P450 family 90, subfamily A, polypeptide 1, cytochrome P450 family 90, subfamily B, polypeptide 1, and cytochrome P450 family 90, subfamily D, polypeptide 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L7D5.3

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