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    VTC5 GDP-L-galactose phosphorylase VITAMIN C DEFECTIVE 5 (VTC5) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835603, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VTC5
    Official Full Name
    GDP-L-galactose phosphorylase VITAMIN C DEFECTIVE 5 (VTC5)
    Primary source
    TAIR:AT5G55120
    Locus tag
    AT5G55120
    See related
    Araport:AT5G55120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MCO15.7; MCO15_7; VITAMIN C DEFECTIVE 5
    Summary
    Encodes a GDP-L-galactose phosphorylase, with similar biochemical properties as VTC2.
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    Genomic context

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    See VTC5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (22369007..22371867)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene SWAP (Suppressor-of-White-APricot)/surp domain-containing protein Neighboring gene Stigma-specific Stig1 family protein Neighboring gene Ribosomal protein L31 Neighboring gene co-factor for nitrate, reductase and xanthine dehydrogenase 5 Neighboring gene Protein of unknown function (PD694200)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction. Linster CL, et al. J Biol Chem, 2008 Jul 4. PMID 18463094, Free PMC Article
    2. Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability. Dowdle J, et al. Plant J, 2007 Nov. PMID 17877701
    3. Blue light diminishes interaction of PAS/LOV proteins, putative blue light receptors in Arabidopsis thaliana, with their interacting partners. Ogura Y, et al. J Plant Res, 2008 Jan. PMID 17982713
    4. Coordinated activation of metabolic pathways for antioxidants and defence compounds by jasmonates and their roles in stress tolerance in Arabidopsis. Sasaki-Sekimoto Y, et al. Plant J, 2005 Nov. PMID 16262714
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis VTC2 and VTC5 proteins are enzymes that guanylylate a conserved active site His residue with GDP-L-galactose, forming L-galactose 1-phosphate for vitamin C synthesis, and regenerate the enzyme with phosphate to form GDP.
      Title: A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction.
    2. Data show that At5g55120, a homologue of GDP-L-galactose phosphorylase (VTC2), encodes a second GDP-L-galactose phosphorylase with similar properties to VTC2.
      Title: Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Miscellaneous features

    • Loc: 22369259-22369321 AT5G55120.uORF2
    NM_124894.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GDP-D-glucose phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-L-galactose phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP-galactose:glucose-1-phosphate guanylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP-galactose:mannose-1-phosphate guanylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quercetin 4'-O-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-ascorbic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ozone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    GDP-L-galactose phosphorylase VITAMIN C DEFECTIVE 5 (VTC5)
    NP_200323.1
    • VITAMIN C DEFECTIVE 5 (VTC5); BEST Arabidopsis thaliana protein match is: mannose-1-phosphate guanylyltransferase (GDP)s;GDP-galactose:mannose-1-phosphate guanylyltransferases;GDP-galactose:glucose-1-phosphate guanylyltransferases;GDP-galactose:myoinositol-1-phosphate guanylyltransferases;glucose-1-phosphate guanylyltransferase (GDP)s;galactose-1-phosphate guanylyltransferase (GDP)s;GDP-D-glucose phosphorylases;quercetin 4'-O-glucosyltransferases (TAIR:AT4G26850.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22369007..22371867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124894.5 → NP_200323.1  GDP-L-galactose phosphorylase VITAMIN C DEFECTIVE 5 (VTC5) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200323.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FLP9
      UniProtKB/TrEMBL
      A0A178UIM1, A0A5S9YGG8
      Conserved Domains (1) summary
      PLN03103
      Location:2 → 391
      PLN03103; GDP-L-galactose-hexose-1-phosphate guanyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FLP9.1

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