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    CYP711A1 cytochrome P450, family 711, subfamily A, polypeptide 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817157, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP711A1
    Official Full Name
    cytochrome P450, family 711, subfamily A, polypeptide 1
    Primary source
    TAIR:AT2G26170
    Locus tag
    AT2G26170
    See related
    Araport:AT2G26170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytochrome P450; family 711; MAX1; MORE AXILLARY BRANCHES 1; polypeptide 1; subfamily A; T1D16.19; T1D16_19
    Summary
    Encodes a protein with similarity to thromboxane-A synthase, member of the CYP711A cytochrome P450 family. MAX1 is a specific repressor of vegetative axillary buds generated by the axillary meristem. Expressed in vascular traces in the rosette stem and axillary buds throughout plant development. Mutants have increased axillary branches. Along with MAX3,4 thought to mediate control of shoot branching via synthesis of a signal molecule which is transported over long distance mediated by MAX2. cDNA supports the existence of the longer transcript predicted for this locus, no cDNA isolated for shorter transcript. MAX1 downregulates 11 genes involved in flavonoid pathway (CHS, CHI, F3H, F3'H, FLS, DFR, ANS, UFGT, RT, AAC and GST).
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    Genomic context

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    See CYP711A1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (11140809..11143360)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor A2 Neighboring gene F-box SKIP23-like protein (DUF295) Neighboring gene IQ-domain 6 Neighboring gene calmodulin-binding family protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carlactone is converted to carlactonoic acid by MAX1 in Arabidopsis and its methyl ester can directly interact with AtD14 in vitro. Abe S, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25425668, Free PMC Article
    2. MAX1, a regulator of the flavonoid pathway, controls vegetative axillary bud outgrowth in Arabidopsis. Lazar G, et al. Proc Natl Acad Sci U S A, 2006 Jan 10. PMID 16387852, Free PMC Article
    3. MAX1 encodes a cytochrome P450 family member that acts downstream of MAX3/4 to produce a carotenoid-derived branch-inhibiting hormone. Booker J, et al. Dev Cell, 2005 Mar. PMID 15737939
    4. A mitochondrial ADXR-ADX-P450 electron transport chain is essential for maternal gametophytic control of embryogenesis in Arabidopsis. Bellido AM, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35046016, Free PMC Article
    5. The Arabidopsis ortholog of rice DWARF27 acts upstream of MAX1 in the control of plant development by strigolactones. Waters MT, et al. Plant Physiol, 2012 Jul. PMID 22623516, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtMYBS1 negatively regulates heat tolerance by directly repressing the expression of MAX1 required for strigolactone biosynthesis in Arabidopsis.
      Title: AtMYBS1 negatively regulates heat tolerance by directly repressing the expression of MAX1 required for strigolactone biosynthesis in Arabidopsis.
    2. Carlactone is converted to carlactonoic acid by MAX1 in Arabidopsis.
      Title: Carlactone is converted to carlactonoic acid by MAX1 in Arabidopsis and its methyl ester can directly interact with AtD14 in vitro.
    3. The MAX1 gene is a particularly strong candidate for contributing to diversification of inputs upstream of MAX2.
      Title: A role for more axillary growth1 (MAX1) in evolutionary diversity in strigolactone signaling upstream of MAX2.
    4. AtD27 operates on a nonmobile precursor upstream of MAX1 in the strigolactone biosynthesis pathway.
      Title: The Arabidopsis ortholog of rice DWARF27 acts upstream of MAX1 in the control of plant development by strigolactones.
    5. MAX1 is implicated in synthesis of the carotenoid-derived branch regulator(s) from the root, it likely links long-distance signaling with local control of bud outgrowth
      Title: MAX1, a regulator of the flavonoid pathway, controls vegetative axillary bud outgrowth in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_128175.3
    NM_179743.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within carotenoid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flavonoid biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within secondary shoot formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 711, subfamily A, polypeptide 1
    NP_565617.2
    • ''cytochrome P450, family 711, subfamily A, polypeptide 1'' (CYP711A1); FUNCTIONS IN: electron carrier activity, monooxygenase activity, iron ion binding, oxygen binding, heme binding; INVOLVED IN: carotenoid biosynthetic process, positive regulation of flavonoid biosynthetic process, regulation of meristem structural organization, secondary shoot formation, auxin polar transport; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 71, subfamily B, polypeptide 35 (TAIR:AT3G26310.1); Has 34245 Blast hits to 33955 proteins in 1742 species: Archae - 52; Bacteria - 5395; Metazoa - 11837; Fungi - 6975; Plants - 8486; Viruses - 3; Other Eukaryotes - 1497 (source: NCBI BLink).
    NP_850074.1
    • ''cytochrome P450, family 711, subfamily A, polypeptide 1'' (CYP711A1); FUNCTIONS IN: electron carrier activity, monooxygenase activity, iron ion binding, oxygen binding, heme binding; INVOLVED IN: carotenoid biosynthetic process, positive regulation of flavonoid biosynthetic process, regulation of meristem structural organization, secondary shoot formation, auxin polar transport; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 81, subfamily D, polypeptide 3 (TAIR:AT4G37340.1); Has 33662 Blast hits to 33590 proteins in 1727 species: Archae - 52; Bacteria - 5395; Metazoa - 11559; Fungi - 6944; Plants - 8228; Viruses - 3; Other Eukaryotes - 1481 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11140809..11143360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128175.3 → NP_565617.2  cytochrome P450, family 711, subfamily A, polypeptide 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565617.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFU2, O64853, Q940L3
      UniProtKB/TrEMBL
      A0A178VR04, A0A5S9X1T3, A0A654F197
      Conserved Domains (1) summary
      cl41757
      Location:75 → 515
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. NM_179743.2 → NP_850074.1  cytochrome P450, family 711, subfamily A, polypeptide 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VR04, A0A5S9X1T3
      Conserved Domains (1) summary
      cl12078
      Location:1 → 411
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B9DFU2.1

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