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    CYP51G1 CYTOCHROME P450 51G1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837712, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP51G1
    Official Full Name
    CYTOCHROME P450 51G1
    Primary source
    TAIR:AT1G11680
    Locus tag
    AT1G11680
    See related
    Araport:AT1G11680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CYP51; CYP51A2; CYTOCHROME P450 51; CYTOCHROME P450 51A2; CYTOCHROME P450 51G1; EMB1738; embryo defective 1738; F25C20.17; F25C20_17
    Summary
    putative obtusifoliol 14-alpha demethylase involved in sterol biosynthesis.
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    Genomic context

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    See CYP51G1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (3938422..3940871)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene MATE efflux family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene BRANCHLESS TRICHOME-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Postembryonic seedling lethality in the sterol-deficient Arabidopsis cyp51A2 mutant is partially mediated by the composite action of ethylene and reactive oxygen species. Kim HB, et al. Plant Physiol, 2010 Jan. PMID 19915013, Free PMC Article
    2. Lipid signaling in plants. Cloning and expression analysis of the obtusifoliol 14alpha-demethylase from Solanum chacoense Bitt., a pollination- and fertilization-induced gene with both obtusifoliol and lanosterol demethylase activity. O'Brien M, et al. Plant Physiol, 2005 Oct. PMID 16169959, Free PMC Article
    3. Arabidopsis cyp51 mutant shows postembryonic seedling lethality associated with lack of membrane integrity. Kim HB, et al. Plant Physiol, 2005 Aug. PMID 16040657, Free PMC Article
    4. Obtusifoliol 14alpha-demethylase (CYP51) antisense Arabidopsis shows slow growth and long life. Kushiro M, et al. Biochem Biophys Res Commun, 2001 Jul 6. PMID 11437378
    5. Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato. Morikawa T, et al. Plant Cell, 2006 Apr. PMID 16531502, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that changes in membrane sterol contents and composition in the cyp51A2 mutant trigger the generation of oxidants and ethylene and eventually induce premature seedling senescence.
      Title: Postembryonic seedling lethality in the sterol-deficient Arabidopsis cyp51A2 mutant is partially mediated by the composite action of ethylene and reactive oxygen species.
    2. The Arabidopsis CYP51A2 gene encodes a functional obtusifoliol 14alpha-demethylase enzyme and plays an essential role in controlling plant growth and development by a sterol-specific pathway.
      Title: Arabidopsis cyp51 mutant shows postembryonic seedling lethality associated with lack of membrane integrity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_101040.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol 14-demethylase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    CYTOCHROME P450 51G1
    NP_172633.1
    • CYTOCHROME P450 51G1 (CYP51G1); FUNCTIONS IN: sterol 14-demethylase activity, oxygen binding; INVOLVED IN: sterol biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: endoplasmic reticulum, plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 4 (TAIR:AT3G19270.1); Has 30265 Blast hits to 30215 proteins in 1662 species: Archae - 71; Bacteria - 5605; Metazoa - 9913; Fungi - 5125; Plants - 8048; Viruses - 6; Other Eukaryotes - 1497 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3938422..3940871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101040.4 → NP_172633.1  CYTOCHROME P450 51G1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172633.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SAA9
      UniProtKB/TrEMBL
      A0A178WII3, A0A5S9TWQ1
      Conserved Domains (1) summary
      cd11042
      Location:68 → 483
      CYP51-like; cytochrome P450 family 51 and similar cytochrome P450s
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SAA9.1

    Gene LinkOut

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