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    eukaryotic translation initiation factor 2 (eIF-2) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844015, updated on 18-Sep-2024

    Summary

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    Official Full Name
    eukaryotic translation initiation factor 2 (eIF-2) family protein
    Primary source
    TAIR:AT1G76810
    Locus tag
    AT1G76810
    See related
    Araport:AT1G76810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F28O16.18; F28O16_18
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (28830902..28836748, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene O-methyltransferase family protein Neighboring gene Vacuolar iron transporter (VIT) family protein Neighboring gene eukaryotic translation initiation factor 2 (eIF-2) family protein Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in eIF5B Confer Thermosensitive and Pleiotropic Phenotypes via Translation Defects in Arabidopsis thaliana. Zhang L, et al. Plant Cell, 2017 Aug. PMID 28808135, Free PMC Article
    2. Interactomics of Qa-SNARE in Arabidopsis thaliana. Fujiwara M, et al. Plant Cell Physiol, 2014 Apr. PMID 24556609
    3. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
    4. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106331.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 (eIF-2) family protein
    NP_177807.3
    • eukaryotic translation initiation factor 2 (eIF-2) family protein; FUNCTIONS IN: translation factor activity, nucleic acid binding, GTP binding, GTPase activity; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Small GTP-binding protein (InterPro:IPR005225), Translation elongation factor EFTu/EF1A, domain 2 (InterPro:IPR004161), Translation initiation factor 2 related (InterPro:IPR015760), Protein synthesis factor, GTP-binding (InterPro:IPR000795), Translation elongation/initiation factor/Ribosomal, beta-barrel (InterPro:IPR009000); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 2 (eIF-2) family protein (TAIR:AT1G76720.1); Has 208612 Blast hits to 135501 proteins in 4311 species: Archae - 1435; Bacteria - 54544; Metazoa - 70572; Fungi - 21896; Plants - 9806; Viruses - 724; Other Eukaryotes - 49635 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28830902..28836748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106331.5 → NP_177807.3  eukaryotic translation initiation factor 2 (eIF-2) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177807.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WUZ8, F4I420
      Conserved Domains (5) summary
      cd01887
      Location:706 → 916
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      PRK04004
      Location:700 → 1294
      PRK04004; translation initiation factor IF-2; Validated
      pfam11987
      Location:1040 → 1141
      IF-2; Translation-initiation factor 2
      cd03703
      Location:927 → 1037
      aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
      cd16266
      Location:1166 → 1260
      IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5
    Nucleotide Protein
    Heading Accession and Version

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