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    CLP2 CLP protease proteolytic subunit 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837797, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLP2
    Official Full Name
    CLP protease proteolytic subunit 2
    Primary source
    TAIR:AT1G12410
    Locus tag
    AT1G12410
    See related
    Araport:AT1G12410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CLP protease proteolytic subunit 2; CLPR2; EMB3146; EMBRYO DEFECTIVE 3146; F5O11.13; F5O11_13; NCLPP2; NUCLEAR-ENCODED CLP PROTEASE P2
    Summary
    Encodes a ClpP-related sequence. Though similar to ClpP proteins, this does not contains the highly conserved catalytic triad of Ser-type proteases (Ser-His-Asp). The name reflects nomenclature described in Adam et. al (2001).
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    Genomic context

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    See CLP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (4223030..4225254)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cornichon family protein Neighboring gene Nucleotide excision repair, TFIIH, subunit TTDA Neighboring gene uncharacterized protein Neighboring gene ACT domain repeat 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Downregulation of ClpR2 leads to reduced accumulation of the ClpPRS protease complex and defects in chloroplast biogenesis in Arabidopsis. Rudella A, et al. Plant Cell, 2006 Jul. PMID 16766689, Free PMC Article
    2. Large scale comparative proteomics of a chloroplast Clp protease mutant reveals folding stress, altered protein homeostasis, and feedback regulation of metabolism. Zybailov B, et al. Mol Cell Proteomics, 2009 Aug. PMID 19423572, Free PMC Article
    3. Modified Clp protease complex in the ClpP3 null mutant and consequences for chloroplast development and function in Arabidopsis. Kim J, et al. Plant Physiol, 2013 May. PMID 23548781, Free PMC Article
    4. Subunit stoichiometry, evolution, and functional implications of an asymmetric plant plastid ClpP/R protease complex in Arabidopsis. Olinares PD, et al. Plant Cell, 2011 Jun. PMID 21712416, Free PMC Article
    5. Identification of a 350-kDa ClpP protease complex with 10 different Clp isoforms in chloroplasts of Arabidopsis thaliana. Peltier JB, et al. J Biol Chem, 2001 May 11. PMID 11278690

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of the proteomics phenotype of clpp3-1 with the clpr2-1 and clpr4-1 phenotypes indicated very similar metabolic and protein homeostasis defects for these Clp core mutants.
      Title: Modified Clp protease complex in the ClpP3 null mutant and consequences for chloroplast development and function in Arabidopsis.
    2. Results show that proteomics data and the role of Clp provide testable hypotheses and putative substrates to further determine the significance of Clp-driven proteolysis.
      Title: Large scale comparative proteomics of a chloroplast Clp protease mutant reveals folding stress, altered protein homeostasis, and feedback regulation of metabolism.
    3. Data suggest that ClpR2 cannot be functionally replaced by other ClpP/R homologues and that the ClpPRS complex is central to chloroplast biogenesis, thylakoid protein homeostasis, and plant development.
      Title: Downregulation of ClpR2 leads to reduced accumulation of the ClpPRS protease complex and defects in chloroplast biogenesis in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101113.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chloroplastic endopeptidase Clp complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 

    General protein information

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    Preferred Names
    CLP protease proteolytic subunit 2
    NP_563907.1
    • CLP protease proteolytic subunit 2 (CLP2); FUNCTIONS IN: serine-type endopeptidase activity; INVOLVED IN: chloroplast organization; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase S14, ClpP (InterPro:IPR001907); BEST Arabidopsis thaliana protein match is: plastid-encoded CLP P (TAIR:ATCG00670.1); Has 13082 Blast hits to 13064 proteins in 2999 species: Archae - 2; Bacteria - 8275; Metazoa - 145; Fungi - 81; Plants - 1076; Viruses - 67; Other Eukaryotes - 3436 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4223030..4225254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101113.4 → NP_563907.1  CLP protease proteolytic subunit 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563907.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93ZD4, Q9XJ36
      UniProtKB/TrEMBL
      A0A178WNM1, A0A5S9U2M2
      Conserved Domains (1) summary
      pfam00574
      Location:86 → 262
      CLP_protease; Clp protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XJ36.1

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