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    UVR3 DNA photolyase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820804, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UVR3
    Official Full Name
    DNA photolyase family protein
    Primary source
    TAIR:AT3G15620
    Locus tag
    AT3G15620
    See related
    Araport:AT3G15620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    6-4 PHOTOLYASE; UV REPAIR DEFECTIVE 3
    Summary
    Required for photorepair of 6-4 photoproducts in Arabidopsis thaliana.
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    Genomic context

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    See UVR3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (5293256..5296811, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene nucleic acid binding protein Neighboring gene uncharacterized protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene ncRNA Neighboring gene plant/protein Neighboring gene uncharacterized protein Neighboring gene Rubredoxin-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 6,4-PP Photolyase Encoded by AtUVR3 is Localized in Nuclei, Chloroplasts and Mitochondria and its Expression is Down-Regulated by Light in a Photosynthesis-Dependent Manner. Katarzyna Banas A, et al. Plant Cell Physiol, 2018 Jan 1. PMID 29069446
    2. Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes. Hitomi K, et al. Proc Natl Acad Sci U S A, 2009 Apr 28. PMID 19359474, Free PMC Article
    3. Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 photoproducts in Arabidopsis thaliana. Nakajima S, et al. Nucleic Acids Res, 1998 Jan 15. PMID 9421527, Free PMC Article
    4. Dynamics and mechanism of repair of ultraviolet-induced (6-4) photoproduct by photolyase. Li J, et al. Nature, 2010 Aug 12. PMID 20657578, Free PMC Article
    5. det1-1-induced UV-C hyposensitivity through UVR3 and PHR1 photolyase gene over-expression. Castells E, et al. Plant J, 2010 Aug. PMID 20487384

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that mitochondrial and chloroplast localization of DNA photolyase AtUVR3 (UVR3) is independent of its N-terminal sequence.
      Title: 6,4-PP Photolyase Encoded by AtUVR3 is Localized in Nuclei, Chloroplasts and Mitochondria and its Expression is Down-Regulated by Light in a Photosynthesis-Dependent Manner.
    2. In darkness, expression of the PHR1 and UVR3 photolyase genes, responsible for photoreactivation, is maintained at a basal level through the positive action of HY5 and HYH photomorphogenesis-promoting transcription factors
      Title: det1-1-induced UV-C hyposensitivity through UVR3 and PHR1 photolyase gene over-expression.
    3. the key step in the repair photocycle is acyclic proton transfer between the enzyme and the substrate
      Title: Dynamics and mechanism of repair of ultraviolet-induced (6-4) photoproduct by photolyase.
    4. regulation of FAD redox properties and radical stability is essential not only for (6-4) photoproduct DNA repair, but also for circadian clock-regulating CRY functions
      Title: Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001035626.2
    NM_112432.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA (6-4) photolyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA (6-4) photolyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pyrimidine dimer repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA photolyase family protein
    NP_001030703.1
    • UV REPAIR DEFECTIVE 3 (UVR3); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), DNA photolyase, N-terminal (InterPro:IPR006050), DNA photolyase, FAD-binding/Cryptochrome, C-terminal (InterPro:IPR005101); BEST Arabidopsis thaliana protein match is: cryptochrome 3 (TAIR:AT5G24850.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_566520.1
    • UV REPAIR DEFECTIVE 3 (UVR3); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), DNA photolyase, N-terminal (InterPro:IPR006050), DNA photolyase, FAD-binding/Cryptochrome, C-terminal (InterPro:IPR005101); BEST Arabidopsis thaliana protein match is: cryptochrome 2 (TAIR:AT1G04400.1); Has 8860 Blast hits to 8829 proteins in 1491 species: Archae - 102; Bacteria - 3068; Metazoa - 397; Fungi - 149; Plants - 721; Viruses - 0; Other Eukaryotes - 4423 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5293256..5296811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035626.2 → NP_001030703.1  DNA photolyase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030703.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48652
      Conserved Domains (3) summary
      TIGR02765
      Location:27 → 428
      crypto_DASH; cryptochrome, DASH family
      pfam00875
      Location:26 → 185
      DNA_photolyase; DNA photolyase
      pfam03441
      Location:240 → 431
      FAD_binding_7; FAD binding domain of DNA photolyase

    2. NM_112432.2 → NP_566520.1  DNA photolyase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566520.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48652, Q2V3V6
      UniProtKB/TrEMBL
      A0A5S9XCT9
      Conserved Domains (2) summary
      COG0415
      Location:26 → 510
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam03441
      Location:315 → 514
      FAD_binding_7; FAD binding domain of DNA photolyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48652.2

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