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    TDX tetraticopeptide domain-containing thioredoxin [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821056, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TDX
    Official Full Name
    tetraticopeptide domain-containing thioredoxin
    Primary source
    TAIR:AT3G17880
    Locus tag
    AT3G17880
    See related
    Araport:AT3G17880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA HSP70-INTERACTING PROTEIN 2; AT3G17870; ATHIP2; ATTDX; HIP; HSC-70 INTERACTING PROTEIN; tetraticopeptide domain-containing thioredoxin
    Summary
    Encodes a thioredoxin-like disulfide reductase. The protein interacts with the yeast Hsp70 protein Ssb2 in vitro. This interaction is sensitive to the redox status of the thioredoxin domain of AtTDX.
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    Genomic context

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    See TDX in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (6123341..6126281)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene jasmonate-zim-domain protein 3 Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redox properties of a thioredoxin-like Arabidopsis protein, AtTDX. Kim SG, et al. Biochim Biophys Acta, 2010 Dec. PMID 20849982
    2. Heat-shock dependent oligomeric status alters the function of a plant-specific thioredoxin-like protein, AtTDX. Lee JR, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19293385, Free PMC Article
    3. Redox control of Hsp70-Co-chaperone interaction revealed by expression of a thioredoxin-like Arabidopsis protein. Vignols F, et al. J Biol Chem, 2003 Feb 14. PMID 12433921
    4. The RING E3 Ligase KEEP ON GOING Modulates JASMONATE ZIM-DOMAIN12 Stability. Pauwels L, et al. Plant Physiol, 2015 Oct. PMID 26320228, Free PMC Article
    5. Arabidopsis RPD3-like histone deacetylases form multiple complexes involved in stress response. Feng C, et al. J Genet Genomics, 2021 May 20. PMID 34144927

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084706.1
    NM_112669.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Hsp70 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein complex oligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraticopeptide domain-containing thioredoxin
    NP_001078175.1
    • tetraticopeptide domain-containing thioredoxin (TDX); FUNCTIONS IN: protein binding, oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: cell redox homeostasis; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Tetratricopeptide-like helical (InterPro:IPR011990), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Tetratricopeptide repeat-containing (InterPro:IPR013026), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: HSP70-interacting protein 1 (TAIR:AT4G22670.1); Has 25327 Blast hits to 23050 proteins in 2977 species: Archae - 386; Bacteria - 12482; Metazoa - 3860; Fungi - 1433; Plants - 2443; Viruses - 7; Other Eukaryotes - 4716 (source: NCBI BLink).
    NP_188415.2
    • tetraticopeptide domain-containing thioredoxin (TDX); FUNCTIONS IN: protein binding, oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: cell redox homeostasis; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Tetratricopeptide-like helical (InterPro:IPR011990), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like (InterPro:IPR017936), Tetratricopeptide repeat-containing (InterPro:IPR013026), Thioredoxin-like fold (InterPro:IPR012336), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: HSP70-interacting protein 1 (TAIR:AT4G22670.1); Has 25378 Blast hits to 23097 proteins in 2986 species: Archae - 386; Bacteria - 12513; Metazoa - 3855; Fungi - 1480; Plants - 2453; Viruses - 7; Other Eukaryotes - 4684 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6123341..6126281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112669.4 → NP_188415.2  tetraticopeptide domain-containing thioredoxin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188415.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7XJ63, Q8LG82, Q8VWG7, Q9LVI2, Q9LVI3
      UniProtKB/TrEMBL
      A0A178VI62, A0A7G2ER26
      Conserved Domains (5) summary
      PLN03088
      Location:117 → 213
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      PRK14552
      Location:200 → 256
      PRK14552; C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Provisional
      cd02947
      Location:292 → 374
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      cd14438
      Location:6 → 44
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:112 → 140
      TPR; TPR repeat [structural motif]

    2. NM_001084706.1 → NP_001078175.1  tetraticopeptide domain-containing thioredoxin [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078175.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VI62
      Conserved Domains (4) summary
      cd02947
      Location:285 → 367
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      cd14438
      Location:6 → 44
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:105 → 133
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:104 → 169
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VWG7.1

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