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    TOP6B topoisomerase 6 subunit B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821626, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOP6B
    Official Full Name
    topoisomerase 6 subunit B
    Primary source
    TAIR:AT3G20780
    Locus tag
    AT3G20780
    See related
    Araport:AT3G20780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTOP6B; BIN3; BRASSINOSTEROID INSENSITIVE 3; ELONGATED HYPOCOTYL 6; HARLEQUIN; HLQ; HYP6; RHL3; ROOT HAIRLESS 3; topoisomerase 6 subunit B; topoisomerase 6 subunit B
    Summary
    Encodes putative eukaryotic homolog of archaebacterial topoisomerase VI subunit B, TOP6B. Is essential for endoreduplication and is involved in cell expansion and cell proliferation. The hlq (harlequin) dwarf mutant has fewer root hair and leaf trichome. It has abnormal epidermal cell and accumulates callose.
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    Genomic context

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    See TOP6B in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Sequence:
    Chromosome: 3; NC_003074.8 (7263900..7268750, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Nse4, component of Smc5/6 DNA repair complex Neighboring gene Ethylene insensitive 3 family protein Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene ncRNA Neighboring gene Cell differentiation, Rcd1-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TOPOISOMERASE 6B is involved in chromatin remodelling associated with control of carbon partitioning into secondary metabolites and cell walls, and epidermal morphogenesis in Arabidopsis. Mittal A, et al. J Exp Bot, 2014 Aug. PMID 24821950, Free PMC Article
    2. An archaebacterial topoisomerase homolog not present in other eukaryotes is indispensable for cell proliferation of plants. Hartung F, et al. Curr Biol, 2002 Oct 15. PMID 12401176
    3. A crucial role for the putative Arabidopsis topoisomerase VI in plant growth and development. Yin Y, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12119417, Free PMC Article
    4. Harlequin (hlq) and short blue root (sbr), two Arabidopsis mutants that ectopically express an abscisic acid- and auxin-inducible transgenic carrot promoter and have pleiotropic effects on morphogenesis. Subramanian S, et al. Plant Mol Biol, 2002 May. PMID 12008902
    5. A genetic screen for mutants defective in IAA1-LUC degradation in Arabidopsis thaliana reveals an important requirement for TOPOISOMERASE6B in auxin physiology. Gilkerson J, et al. Plant Signal Behav, 2014. PMID 25482814, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicated that AtPRD1 may act as a bridge protein to interact with AtPRD3 and AtDFO, and interact directly with the Topo VI-like proteins MTOPVIB, AtSPO11-1 and AtSPO11-2 to take part in DNA double-strand break formation in Arabidopsis.
      Title: MTOPVIB interacts with AtPRD1 and plays important roles in formation of meiotic DNA double-strand breaks in Arabidopsis.
    2. These data suggest that increased IAA1-luciferase fusion protein half-life in top6b-7 probably results from a combination of both lower endogenous IAA levels and reduced sensitivity to auxin.
      Title: A genetic screen for mutants defective in IAA1-LUC degradation in Arabidopsis thaliana reveals an important requirement for TOPOISOMERASE6B in auxin physiology.
    3. role in the regulation of chromatin remodelling to mediate development in response to environmental and hormonal signals
      Title: TOPOISOMERASE 6B is involved in chromatin remodelling associated with control of carbon partitioning into secondary metabolites and cell walls, and epidermal morphogenesis in Arabidopsis.
    4. A functional connection between COP1 and the TOPOVI in plants links COP1-dependent development with the regulation of endoreduplication.
      Title: MIDGET connects COP1-dependent development with endoreduplication in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_112969.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to brassinosteroid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    topoisomerase 6 subunit B
    NP_188714.2
    • topoisomerase 6 subunit B (TOP6B); CONTAINS InterPro DOMAIN/s: DNA topoisomerase VI, subunit B, transducer (InterPro:IPR015320), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), ATPase-like, ATP-binding domain (InterPro:IPR003594); Has 873 Blast hits to 542 proteins in 165 species: Archae - 495; Bacteria - 44; Metazoa - 2; Fungi - 2; Plants - 34; Viruses - 0; Other Eukaryotes - 296 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7263900..7268750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112969.3 → NP_188714.2  topoisomerase 6 subunit B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188714.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5V6, Q9LT43
      UniProtKB/TrEMBL
      A0A5S9XE17, A0A654FA26
      Conserved Domains (1) summary
      PRK04184
      Location:22 → 595
      PRK04184; DNA topoisomerase VI subunit B; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5V6.1

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