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    IOS1 Leucine-rich repeat protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841606, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IOS1
    Official Full Name
    Leucine-rich repeat protein kinase family protein
    Primary source
    TAIR:AT1G51800
    Locus tag
    AT1G51800
    See related
    Araport:AT1G51800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F19C24.3; F19C24_3; IMPAIRED OOMYCETE SUSCEPTIBILITY 1
    Summary
    The gene encodes a putative member of the LRR-RLK protein family. Expressin and mutant analysis revealed that it contributes to the interaction between Arabidopsis and Hyaloperonospora arabidopsidis. and
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    Genomic context

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    See IOS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (19214072..19218053)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene IAA-amino acid hydrolase ILR1-like 5 Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene miscRNA Neighboring gene Leucine-rich repeat protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The receptor kinase IMPAIRED OOMYCETE SUSCEPTIBILITY1 attenuates abscisic acid responses in Arabidopsis. Hok S, et al. Plant Physiol, 2014 Nov. PMID 25274985, Free PMC Article
    2. Endogenous Arabidopsis messenger RNAs transported to distant tissues. Thieme CJ, et al. Nat Plants, 2015 Mar 23. PMID 27247031
    3. The Arabidopsis Malectin-Like/LRR-RLK IOS1 Is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity. Yeh YH, et al. Plant Cell, 2016 Jul. PMID 27317676, Free PMC Article
    4. A brassinosteroid-signaling kinase interacts with multiple receptor-like kinases in Arabidopsis. Xu P, et al. Mol Plant, 2014 Feb. PMID 24051702, Free PMC Article
    5. An Arabidopsis (malectin-like) leucine-rich repeat receptor-like kinase contributes to downy mildew disease. Hok S, et al. Plant Cell Environ, 2011 Nov. PMID 21711359

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis Malectin-Like/LRR-RLK IOS1 Is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity
      Title: The Arabidopsis Malectin-Like/LRR-RLK IOS1 Is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity.
    2. IOS1 participates in fungal pathogen-mediated reprogramming of the Arabidopssi.IOS1 attenuates abscisic acid responses in Arabidopsis.
      Title: The receptor kinase IMPAIRED OOMYCETE SUSCEPTIBILITY1 attenuates abscisic acid responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104059.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to oomycetes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of defense response to oomycetes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of defense response by callose deposition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to chitin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to molecule of bacterial origin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to molecule of fungal origin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oomycetes IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to oomycetes IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pollen tube IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat protein kinase family protein
    NP_175591.1
    • Leucine-rich repeat protein kinase family protein; FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: endomembrane system; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT1G51860.1); Has 161787 Blast hits to 121896 proteins in 4448 species: Archae - 101; Bacteria - 13971; Metazoa - 43453; Fungi - 9805; Plants - 75517; Viruses - 389; Other Eukaryotes - 18551 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19214072..19218053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104059.3 → NP_175591.1  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175591.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7FL10, Q9C8I6
      UniProtKB/TrEMBL
      A0A178WKL9
      Conserved Domains (4) summary
      cd14066
      Location:592 → 856
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      sd00033
      Location:412 → 433
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12819
      Location:32 → 352
      Malectin_like; Carbohydrate-binding protein of the ER
      cl26793
      Location:409 → 498
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C8I6.1

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