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    HDG12 homeodomain GLABROUS 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838371, updated on 31-Oct-2024

    Summary

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    Official Symbol
    HDG12
    Official Full Name
    homeodomain GLABROUS 12
    Primary source
    TAIR:AT1G17920
    Locus tag
    AT1G17920
    See related
    Araport:AT1G17920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2H15.14; F2H15_14; homeodomain GLABROUS 12
    Summary
    Encodes a homeobox-leucine zipper family protein belonging to the HD-ZIP IV family. Together with HDG11, it is involved in trichome branching.
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    Genomic context

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    See HDG12 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (6161870..6165820, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Wall-associated kinase family protein Neighboring gene ncRNA Neighboring gene Aminotransferase-like, plant mobile domain family protein Neighboring gene Endosomal targeting BRO1-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HD-ZIP IV genes are essential for embryo initial cell polarization and the radial axis formation in Arabidopsis. Tanaka S, et al. Curr Biol, 2024 Oct 21. PMID 39303713
    2. Mutations in epidermis-specific HD-ZIP IV genes affect floral organ identity in Arabidopsis thaliana. Kamata N, et al. Plant J, 2013 Aug. PMID 23590515
    3. Characterization of the class IV homeodomain-Leucine Zipper gene family in Arabidopsis. Nakamura M, et al. Plant Physiol, 2006 Aug. PMID 16778018, Free PMC Article
    4. AIL and HDG proteins act antagonistically to control cell proliferation. Horstman A, et al. Development, 2015 Feb 1. PMID 25564655
    5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HD-ZIP IV genes are essential for embryo initial cell polarization and the radial axis formation in Arabidopsis.
      Title: HD-ZIP IV genes are essential for embryo initial cell polarization and the radial axis formation in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_101655.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of floral organ identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome branching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain GLABROUS 12
    NP_564041.2
    • homeodomain GLABROUS 12 (HDG12); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: trichome branching, regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeodomain GLABROUS 11 (TAIR:AT1G73360.1); Has 11255 Blast hits to 11173 proteins in 538 species: Archae - 0; Bacteria - 0; Metazoa - 8589; Fungi - 214; Plants - 2276; Viruses - 3; Other Eukaryotes - 173 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6161870..6165820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332324.1 → NP_001323262.1  homeodomain GLABROUS 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q944S7, Q9LMT8
      UniProtKB/TrEMBL
      A0A178WQ45, A0A654EAX3, C0SUW2
      Conserved Domains (2) summary
      cd08875
      Location:210 → 436
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:27 → 77
      Homeobox; Homeobox domain

    2. NM_101655.3 → NP_564041.2  homeodomain GLABROUS 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564041.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q944S7, Q9LMT8
      UniProtKB/TrEMBL
      A0A178WQ45, A0A654EAX3, C0SUW2
      Conserved Domains (2) summary
      cd08875
      Location:210 → 436
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:27 → 77
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LMT8.1

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