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    MEKK3 MAPK/ERK kinase kinase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826406, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MEKK3
    Official Full Name
    MAPK/ERK kinase kinase 3
    Primary source
    TAIR:AT4G08470
    Locus tag
    AT4G08470
    See related
    Araport:AT4G08470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MAPK/ERK kinase kinase 3; MAPKKK10; T15F16.2; T15F16_2
    Summary
    Encodes a member of the A1 subgroup of the MEKK (MAPK/ERK kinase kinase) family. MEKK is another name for Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK or MAP3K). This subgroup has four members: At4g08500 (MEKK1, also known as ARAKIN, MAP3Kb1, MAPKKK8), At4g08480 (MEKK2, also known as MAP3Kb4, MAPKKK9), At4g08470 (MEKK3, also known as MAP3Kb3, MAPKKK10) and At4g12020 (MEKK4, also known as MAP3Kb5, MAPKKK11, WRKY19). Nomenclatures for mitogen-activated protein kinases are described in Trends in Plant Science 2002, 7(7):301.
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    Genomic context

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    See MEKK3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (5383688..5387260, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene BTB/POZ domain-containing protein Neighboring gene hypothetical protein (DUF1644) Neighboring gene ncRNA Neighboring gene mitogen-activated protein kinase kinase kinase 9 Neighboring gene Defensin-like (DEFL) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Back From the Dead: The Atypical Kinase Activity of a Pseudokinase Regulator of Cation Fluxes During Inducible Immunity. Brauer EK, et al. Front Plant Sci, 2022. PMID 36035673, Free PMC Article
    2. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_001340589.1
    NM_116916.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MAPK/ERK kinase kinase 3
    NP_192587.1
    • MAPK/ERK kinase kinase 3 (MEKK3); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAPK/ERK kinase kinase 1 (TAIR:AT4G08500.1); Has 127289 Blast hits to 125542 proteins in 4465 species: Archae - 126; Bacteria - 13573; Metazoa - 48244; Fungi - 12466; Plants - 31976; Viruses - 540; Other Eukaryotes - 20364 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      5383688..5387260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001340588.1 → NP_001329232.1  MAPK/ERK kinase kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V2Y2, A0A1P8B722

    2. NM_116916.4 → NP_192587.1  MAPK/ERK kinase kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192587.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81473, O82650, Q84W26, Q9M0T3
      UniProtKB/TrEMBL
      A0A5S9XQE8
      Conserved Domains (1) summary
      cl21453
      Location:302 → 557
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001340589.1 → NP_001329233.1  MAPK/ERK kinase kinase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B727, A0A5S9XQE8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M0T3.1

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