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    CIPK8 CBL-interacting protein kinase 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828542, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CIPK8
    Official Full Name
    CBL-interacting protein kinase 8
    Primary source
    TAIR:AT4G24400
    Locus tag
    AT4G24400
    See related
    Araport:AT4G24400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCIPK8; CBL-interacting protein kinase 8; PKS11; PROTEIN KINASE 11; SNF1-RELATED PROTEIN KINASE 3.13; SnRK3.13; T22A6.230; T22A6_230
    Summary
    Encodes a CBL (calcineurin B-like calcium sensor proteins) -interacting serine/threonine protein kinase. Regulates the low-affinity phase of the primary nitrate response.
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    Genomic context

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    See CIPK8 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (12616979..12620714)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene dihydrofolate reductase Neighboring gene RNI-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtCIPK8, a CBL-interacting protein kinase, regulates the low-affinity phase of the primary nitrate response. Hu HC, et al. Plant J, 2009 Jan. PMID 18798873
    2. Biochemical and functional characterization of PKS11, a novel Arabidopsis protein kinase. Gong D, et al. J Biol Chem, 2002 Aug 2. PMID 12029080
    3. The protein kinase complex CBL10-CIPK8-SOS1 functions in Arabidopsis to regulate salt tolerance. Yin X, et al. J Exp Bot, 2020 Mar 25. PMID 31858132, Free PMC Article
    4. A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2. Ohta M, et al. Proc Natl Acad Sci U S A, 2003 Sep 30. PMID 14504388, Free PMC Article
    5. Calcium sensors and their interacting protein kinases: genomics of the Arabidopsis and rice CBL-CIPK signaling networks. Kolukisaoglu U, et al. Plant Physiol, 2004 Jan. PMID 14730064, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The protein kinase complex CBL10-CIPK8-SOS1 functions in Arabidopsis to regulate salt tolerance.
      Title: The protein kinase complex CBL10-CIPK8-SOS1 functions in Arabidopsis to regulate salt tolerance.
    2. CIPK8 is rapidly induced by nitrate, and positively regulates the nitrate-induced expression of primary nitrate response genes.
      Title: AtCIPK8, a CBL-interacting protein kinase, regulates the low-affinity phase of the primary nitrate response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084973.1
    NM_118573.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    acts_upstream_of_or_within protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucose TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nitrate IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nitrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    CBL-interacting protein kinase 8
    NP_001078442.1
    • CBL-interacting protein kinase 8 (CIPK8); FUNCTIONS IN: protein kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation, response to nitrate, root development, response to glucose stimulus; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT5G35410.1); Has 132609 Blast hits to 130467 proteins in 4740 species: Archae - 192; Bacteria - 15427; Metazoa - 49318; Fungi - 12831; Plants - 32044; Viruses - 538; Other Eukaryotes - 22259 (source: NCBI BLink).
    NP_194171.1
    • CBL-interacting protein kinase 8 (CIPK8); FUNCTIONS IN: protein kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation, response to nitrate, root development, response to glucose stimulus; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT5G35410.1); Has 132292 Blast hits to 130130 proteins in 4671 species: Archae - 192; Bacteria - 15224; Metazoa - 49173; Fungi - 13311; Plants - 31935; Viruses - 538; Other Eukaryotes - 21919 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12616979..12620714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118573.4 → NP_194171.1  CBL-interacting protein kinase 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MR95, Q9C5S5, Q9STV4
      UniProtKB/TrEMBL
      A0A178V2J3, A0A5S9XVV4
      Conserved Domains (2) summary
      cd12195
      Location:308 → 423
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      cl21453
      Location:8 → 261
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001084973.1 → NP_001078442.1  CBL-interacting protein kinase 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078442.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JQW5
      Conserved Domains (3) summary
      cd12195
      Location:308 → 387
      CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
      smart00220
      Location:9 → 262
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:8 → 261
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9STV4.1

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