CBF1 C-repeat/DRE binding factor 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CBF1
Official Full Name: C-repeat/DRE binding factor 1
Primary source: TAIR:AT4G25490
Locus tag: AT4G25490
See related: Araport:AT4G25490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCBF1; C-repeat/DRE binding factor 1; DRE BINDING PROTEIN 1B; DREB1B; T30C3.11; TRANSCRIPTIONAL ACTIVATOR CBF1
Summary: Transcriptional activator that binds to the DRE/CRT regulatory element and induces COR (cold-regulated) gene expression increasing plant freezing tolerance. It encodes a member of the DREB subfamily A-1 of ERF/AP2 transcription factor family (CBF1). The protein contains one AP2 domain. There are six members in this subfamily, including CBF1, CBF2, and CBF3. This gene is involved in response to low temperature and abscisic acid.
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Genomic context

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See CBF1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (13021780..13022996, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional Divergence in Orthologous Transcription Factors: Insights from AtCBF2/3/1 and OsDREB1C.
Title: Functional Divergence in Orthologous Transcription Factors: Insights from AtCBF2/3/1 and OsDREB1C.
The non-coding RNA SVALKA locus produces a cis-natural antisense transcript that negatively regulates the expression of CBF1 and biomass production at normal temperatures.
Title: The non-coding RNA SVALKA locus produces a cis-natural antisense transcript that negatively regulates the expression of CBF1 and biomass production at normal temperatures.
Genotype-dependent contribution of CBF transcription factors to long-term acclimation to high light and cool temperature.
Title: Genotype-dependent contribution of CBF transcription factors to long-term acclimation to high light and cool temperature.
The direct targets of CBFs: In cold stress response and beyond.
Title: The direct targets of CBFs: In cold stress response and beyond.
The cold response regulator CBF1 promotes Arabidopsis hypocotyl growth at ambient temperatures.
Title: The cold response regulator CBF1 promotes Arabidopsis hypocotyl growth at ambient temperatures.
STCH4/REIL2 Confers Cold Stress Tolerance in Arabidopsis by Promoting rRNA Processing and CBF Protein Translation.
Title: STCH4/REIL2 Confers Cold Stress Tolerance in Arabidopsis by Promoting rRNA Processing and CBF Protein Translation.
This study reveals the essential functions of C-repeat binding factors (CBF) in chilling stress response and cold acclimation, as well as defines a set of genes as CBF regulon.
Title: The cbfs triple mutants reveal the essential functions of CBFs in cold acclimation and allow the definition of CBF regulons in Arabidopsis.
CBFs play an important role in the trade-off between cold tolerance and plant growth through the precise regulation of COR genes in the complicated transcriptional network.
Title: The precise regulation of different COR genes by individual CBF transcription factors in Arabidopsis thaliana.
the three CBF genes together are required for cold acclimation and freezing tolerance.
Title: Mutational Evidence for the Critical Role of CBF Transcription Factors in Cold Acclimation in Arabidopsis.
Data indicate that the C-repeat binding factor (CBF) locus includes three genes - CBF1, CBF2 and CBF3 (AT4G25480) - that are induced by low temperature and encode transcription factors.
Title: Natural variation in the C-repeat binding factor cold response pathway correlates with local adaptation of Arabidopsis ecotypes.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_118681.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cold acclimation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cold acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: C-repeat/DRE binding factor 1

NP_567721.1

C-repeat/DRE binding factor 1 (CBF1); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: C-repeat/DRE binding factor 2 (TAIR:AT4G25470.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

13021780..13022996 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118681.4 → NP_567721.1 C-repeat/DRE binding factor 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567721.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65611, P93835, Q5QE71

UniProtKB/TrEMBL

A0A178V6X5, B2BIS9, B6DTR3

Conserved Domains (1) summary

cd00018
Location:46 → 106

AP2; DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor ...