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    CAK1AT CDK-activating kinase 1AT [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829019, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAK1AT
    Official Full Name
    CDK-activating kinase 1AT
    Primary source
    TAIR:AT4G28980
    Locus tag
    AT4G28980
    See related
    Araport:AT4G28980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CDK-activating kinase 1AT; CDKF;1; CYCLIN-DEPENDENT KINASE F;1; F19B15.10; F19B15_10
    Summary
    Encodes a CDK-activating kinase that regulates root initial cell differentiation. Phosphorylates CDKD2 and CDKD3, but not CDKD1. Controls CDK activities and basal transcription.
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    Genomic context

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    See CAK1AT in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (14288379..14290913)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene RNA-binding protein-like protein Neighboring gene Tesmin/TSO1-like CXC domain-containing protein Neighboring gene Enoyl-CoA hydratase/isomerase family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis cyclin-dependent kinase-activating kinase CDKF;1 is a major regulator of cell proliferation and cell expansion but is dispensable for CDKA activation. Takatsuka H, et al. Plant J, 2009 Aug. PMID 19368694
    2. A cyclin-dependent kinase-activating kinase regulates differentiation of root initial cells in Arabidopsis. Umeda M, et al. Proc Natl Acad Sci U S A, 2000 Nov 21. PMID 11069305, Free PMC Article
    3. CDKF;1 and CDKD protein kinases regulate phosphorylation of serine residues in the C-terminal domain of Arabidopsis RNA polymerase II. Hajheidari M, et al. Plant Cell, 2012 Apr. PMID 22547781, Free PMC Article
    4. A distinct cyclin-dependent kinase-activating kinase of Arabidopsis thaliana. Umeda M, et al. Proc Natl Acad Sci U S A, 1998 Apr 28. PMID 9560221, Free PMC Article
    5. Diverse phosphoregulatory mechanisms controlling cyclin-dependent kinase-activating kinases in Arabidopsis. Shimotohno A, et al. Plant J, 2006 Sep. PMID 16856985

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ser phosphorylation of Arabidopsis thaliana RNAPII CTD is governed by CYCLIN-DEPENDENT KINASE F;1.
      Title: CDKF;1 and CDKD protein kinases regulate phosphorylation of serine residues in the C-terminal domain of Arabidopsis RNA polymerase II.
    2. CDKF;1 is dispensable for CDKA;1 activation but is essential for maintaining a steady-state level of CDKD;2. CDKF;1 mutants have severe defects in cell division, cell elongation and endoreduplication.
      Title: The Arabidopsis cyclin-dependent kinase-activating kinase CDKF;1 is a major regulator of cell proliferation and cell expansion but is dispensable for CDKA activation.
    3. CDKF;1 plays a major role in cyclin-dependent kinase and carboxy-terminal domain phosphorylation.
      Title: Diverse phosphoregulatory mechanisms controlling cyclin-dependent kinase-activating kinases in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001341955.1
    NM_119042.5
    NM_179137.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein kinase activating kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within maintenance of root meristem identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    CDK-activating kinase 1AT
    NP_194627.1
    • CDK-activating kinase 1AT (CAK1AT); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase D1;3 (TAIR:AT1G18040.1); Has 87352 Blast hits to 72841 proteins in 3452 species: Archae - 58; Bacteria - 8929; Metazoa - 34591; Fungi - 11921; Plants - 15740; Viruses - 134; Other Eukaryotes - 15979 (source: NCBI BLink).
    NP_849468.1
    • CDK-activating kinase 1AT (CAK1AT); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: cyclin-dependent kinase D1;3 (TAIR:AT1G18040.1); Has 87352 Blast hits to 72841 proteins in 3452 species: Archae - 58; Bacteria - 8929; Metazoa - 34591; Fungi - 11921; Plants - 15740; Viruses - 134; Other Eukaryotes - 15979 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14288379..14290913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179137.3 → NP_849468.1  CDK-activating kinase 1AT [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849468.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80345
      UniProtKB/TrEMBL
      A0A178USG8, A0A384LBL5, B9DFZ7
      Conserved Domains (1) summary
      cl21453
      Location:20 → 430
      PKc_like; Protein Kinases, catalytic domain

    2. NM_119042.5 → NP_194627.1  CDK-activating kinase 1AT [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194627.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80345
      UniProtKB/TrEMBL
      A0A178USG8, A0A384LBL5, B9DFZ7
      Conserved Domains (1) summary
      cl21453
      Location:20 → 430
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001341955.1 → NP_001329562.1  CDK-activating kinase 1AT [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80345
      UniProtKB/TrEMBL
      A0A178USG8, A0A384LBL5, B9DFZ7
      Conserved Domains (1) summary
      cl21453
      Location:20 → 430
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80345.1

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