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    Dihydropterin pyrophosphokinase / Dihydropteroate synthase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829123, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Dihydropterin pyrophosphokinase / Dihydropteroate synthase
    Primary source
    TAIR:AT4G30000
    Locus tag
    AT4G30000
    See related
    Araport:AT4G30000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6G3.30; F6G3_30
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (14670156..14672669, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene fasciclin-like arabinogalactan protein Neighboring gene Leucine-rich repeat transmembrane protein kinase protein Neighboring gene ATP-dependent RNA helicase Neighboring gene PA-domain containing subtilase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam. Vadlamani G, et al. Plant Commun, 2022 Jul 11. PMID 35605193, Free PMC Article
    2. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article
    3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203939.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydropteroate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Dihydropterin pyrophosphokinase / Dihydropteroate synthase
    NP_001190868.1
    • Dihydropterin pyrophosphokinase / Dihydropteroate synthase; FUNCTIONS IN: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity, dihydropteroate synthase activity; INVOLVED IN: pteridine and derivative metabolic process, cellular metabolic process, folic acid and derivative biosynthetic process; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dihydropteroate synthase-like (InterPro:IPR011005), 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (InterPro:IPR000550), Dihydropteroate synthase (InterPro:IPR006390), Pterin-binding (InterPro:IPR000489); BEST Arabidopsis thaliana protein match is: Dihydropterin pyrophosphokinase / Dihydropteroate synthase (TAIR:AT1G69190.1).
    NP_194729.1
    • Dihydropterin pyrophosphokinase / Dihydropteroate synthase; FUNCTIONS IN: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity, dihydropteroate synthase activity; INVOLVED IN: pteridine and derivative metabolic process, cellular metabolic process, folic acid and derivative biosynthetic process; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dihydropteroate synthase-like (InterPro:IPR011005), 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (InterPro:IPR000550), Dihydropteroate synthase (InterPro:IPR006390), Pterin-binding (InterPro:IPR000489); BEST Arabidopsis thaliana protein match is: Dihydropterin pyrophosphokinase / Dihydropteroate synthase (TAIR:AT1G69190.1); Has 14894 Blast hits to 14858 proteins in 2526 species: Archae - 148; Bacteria - 9690; Metazoa - 8; Fungi - 166; Plants - 69; Viruses - 0; Other Eukaryotes - 4813 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14670156..14672669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119146.3 → NP_194729.1  Dihydropterin pyrophosphokinase / Dihydropteroate synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194729.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JPH1, Q9SZV3
      UniProtKB/TrEMBL
      A0A178UTC5, A0A5S9XXJ9, A0A7G2F4W3
      Conserved Domains (2) summary
      cd00739
      Location:273 → 544
      DHPS; DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and ...
      pfam01288
      Location:90 → 215
      HPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)

    2. NM_001203939.1 → NP_001190868.1  Dihydropterin pyrophosphokinase / Dihydropteroate synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F4W3
      Conserved Domains (3) summary
      COG0294
      Location:267 → 545
      FolP; Dihydropteroate synthase [Coenzyme transport and metabolism]
      cd00739
      Location:273 → 541
      DHPS; DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and ...
      pfam01288
      Location:90 → 215
      HPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SZV3.1

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