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    GLDH L-galactono-1,4-lactone dehydrogenase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823948, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLDH
    Official Full Name
    L-galactono-1,4-lactone dehydrogenase
    Primary source
    TAIR:AT3G47930
    Locus tag
    AT3G47930
    See related
    Araport:AT3G47930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''L-galactono-1; 4-LACTONE DEHYDOROGENASE; 4-lactone dehydrogenase; 4-lactone dehydrogenase''; ATGLDH; L-galactono-1; L-GALACTONO-1
    Summary
    L-Galactono-1,4-lactone dehydrogenase, catalyzes the final step of ascorbate biosynthesis
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    Genomic context

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    See GLDH in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (17684322..17687661)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ubiquitin carboxyl-terminal hydrolase-related protein Neighboring gene Ta11-like non-LTR retrotransposon Neighboring gene DNAJ heat shock family protein Neighboring gene H[+]-ATPase 4 Neighboring gene Major facilitator superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. L-Galactono-1,4-lactone dehydrogenase is an assembly factor of the membrane arm of mitochondrial complex I in Arabidopsis. Schimmeyer J, et al. Plant Mol Biol, 2016 Jan. PMID 26520835, Free PMC Article
    2. L-galactono-1,4-lactone dehydrogenase (GLDH) forms part of three subcomplexes of mitochondrial complex I in Arabidopsis thaliana. Schertl P, et al. J Biol Chem, 2012 Apr 27. PMID 22378782, Free PMC Article
    3. Galactonolactone dehydrogenase requires a redox-sensitive thiol for optimal production of vitamin C. Leferink NG, et al. Plant Physiol, 2009 Jun. PMID 19369590, Free PMC Article
    4. L-galactono-1,4-lactone dehydrogenase is required for the accumulation of plant respiratory complex I. Pineau B, et al. J Biol Chem, 2008 Nov 21. PMID 18799460
    5. l-Galactono-gamma-lactone dehydrogenase from Arabidopsis thaliana, a flavoprotein involved in vitamin C biosynthesis. Leferink NG, et al. FEBS J, 2008 Feb. PMID 18190525

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GLDH is a dual-function protein that has a second, non-enzymatic function in complex I assembly as a plant-specific assembly factor.
      Title: L-Galactono-1,4-lactone dehydrogenase is an assembly factor of the membrane arm of mitochondrial complex I in Arabidopsis.
    2. a role of GLDH during complex I formation, which is based on its binding to specific assembly intermediates.
      Title: L-galactono-1,4-lactone dehydrogenase (GLDH) forms part of three subcomplexes of mitochondrial complex I in Arabidopsis thaliana.
    3. Recombinant GALDH from Arabidopsis thaliana is inactivated by hydrogen peroxide due to selective oxidation of cysteine (Cys)-340, located in the cap domain. [GALDH]
      Title: Galactonolactone dehydrogenase requires a redox-sensitive thiol for optimal production of vitamin C.
    4. L-galactono-1,4-lactone dehydrogenase is required for the accumulation of respiratory complex I
      Title: L-galactono-1,4-lactone dehydrogenase is required for the accumulation of plant respiratory complex I.
    5. Data show that AtGALDH forms a flavin N5 sulfite adduct and that AtGALDH lacks the histidine involved in covalent FAD binding, but contains a leucine instead.
      Title: l-Galactono-gamma-lactone dehydrogenase from Arabidopsis thaliana, a flavoprotein involved in vitamin C biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339340.1
    NM_114662.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables D-arabinono-1,4-lactone oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-gulono-1,4-lactone dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactonolactone dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-ascorbic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-ascorbic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-ascorbic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-galactono-1,4-lactone dehydrogenase
    NP_001319706.1
    • ''L-galactono-1,4-lactone dehydrogenase'' (GLDH); CONTAINS InterPro DOMAIN/s: D-arabinono-1,4-lactone oxidase (InterPro:IPR007173), FAD-binding, type 2 (InterPro:IPR016166), Galactonolactone dehydrogenase (InterPro:IPR010029), Actin-binding FH2 (InterPro:IPR015425), FAD linked oxidase, N-terminal (InterPro:IPR006094); BEST Arabidopsis thaliana protein match is: D-arabinono-1,4-lactone oxidase family protein (TAIR:AT5G56490.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_190376.1
    • ''L-galactono-1,4-lactone dehydrogenase'' (GLDH); FUNCTIONS IN: galactonolactone dehydrogenase activity, L-gulono-1,4-lactone dehydrogenase activity; INVOLVED IN: L-ascorbic acid biosynthetic process; LOCATED IN: mitochondrion, plastid; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: D-arabinono-1,4-lactone oxidase (InterPro:IPR007173), FAD-binding, type 2 (InterPro:IPR016166), Galactonolactone dehydrogenase (InterPro:IPR010029), Actin-binding FH2 (InterPro:IPR015425), FAD linked oxidase, N-terminal (InterPro:IPR006094); BEST Arabidopsis thaliana protein match is: D-arabinono-1,4-lactone oxidase family protein (TAIR:AT5G56490.1); Has 6177 Blast hits to 6159 proteins in 1453 species: Archae - 118; Bacteria - 3787; Metazoa - 393; Fungi - 445; Plants - 381; Viruses - 3; Other Eukaryotes - 1050 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17684322..17687661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114662.3 → NP_190376.1  L-galactono-1,4-lactone dehydrogenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190376.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H4I4, Q8GY16, Q9MAX4, Q9SU56
      UniProtKB/TrEMBL
      A0A178VN92, A0A5S9XJG6
      Conserved Domains (1) summary
      TIGR01676
      Location:62 → 604
      GLDHase; galactonolactone dehydrogenase

    2. NM_001339340.1 → NP_001319706.1  L-galactono-1,4-lactone dehydrogenase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2H1ZEJ8
      Conserved Domains (1) summary
      TIGR01676
      Location:62 → 562
      GLDHase; galactonolactone dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SU56.1

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