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    PDIL1-3 PDI-like 1-3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824661, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PDIL1-3
    Official Full Name
    PDI-like 1-3
    Primary source
    TAIR:AT3G54960
    Locus tag
    AT3G54960
    See related
    Araport:AT3G54960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PROTEIN DISULFIDE ISOMERASE 1; ATPDI1; ATPDIL1-3; PDI-like 1-3; PDI1; PROTEIN DISULFIDE ISOMERASE 1; T15C9.4
    Summary
    Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. Transcript levels for this gene are up-regulated in response to three different chemical inducers of ER stress (dithiothreitol, beta-mercaptoethanol, and tunicamycin). Neither AtIRE1-2 nor AtbZIP60 appear to be required for this response.
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    Genomic context

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    See PDIL1-3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (20363260..20366874, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Papain family cysteine protease Neighboring gene patatin-like protein 6 Neighboring gene D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Integrase-type DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana. Lu DP, et al. Mol Genet Genomics, 2008 Sep. PMID 18574595
    2. Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing. Palm D, et al. Nucleic Acids Res, 2019 Feb 28. PMID 30576513, Free PMC Article
    3. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
    5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125370.1
    NM_115353.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to endoplasmic reticulum stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    PDI-like 1-3
    NP_001118842.1
    • PDI-like 1-3 (PDIL1-3); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: response to endoplasmic reticulum stress; LOCATED IN: endoplasmic reticulum, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Protein disulphide isomerase (InterPro:IPR005792), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: PDI-like 1-4 (TAIR:AT5G60640.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_191056.2
    • PDI-like 1-3 (PDIL1-3); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: response to endoplasmic reticulum stress; LOCATED IN: endoplasmic reticulum, plasma membrane, chloroplast; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Disulphide isomerase (InterPro:IPR005788), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Protein disulphide isomerase (InterPro:IPR005792), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: PDI-like 1-4 (TAIR:AT5G60640.1); Has 26348 Blast hits to 17789 proteins in 2915 species: Archae - 261; Bacteria - 12527; Metazoa - 4679; Fungi - 1534; Plants - 2199; Viruses - 17; Other Eukaryotes - 5131 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20363260..20366874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115353.5 → NP_191056.2  PDI-like 1-3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191056.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H5N9, Q8VX13, Q9SV44
      UniProtKB/TrEMBL
      A0A178VF09, A0A5S9XLM3
      Conserved Domains (1) summary
      TIGR01130
      Location:99 → 553
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    2. NM_001125370.1 → NP_001118842.1  PDI-like 1-3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118842.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VX13
      Conserved Domains (5) summary
      cd02981
      Location:207 → 306
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02982
      Location:318 → 418
      PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:439 → 508
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      TIGR01130
      Location:99 → 507
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:104 → 203
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VX13.1

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