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    CRF6 cytokinin response factor 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825336, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRF6
    Official Full Name
    cytokinin response factor 6
    Primary source
    TAIR:AT3G61630
    Locus tag
    AT3G61630
    See related
    Araport:AT3G61630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytokinin response factor 6
    Summary
    CRF6 encodes one of the six cytokinin response factors. CRF5 belongs to the AP2/ERF superfamily of the transcriptional factors. CRF proteins rapidly relocalize to the nucleus in response to cytokinin. Analysis of loos-of-function mutants revealed that the CRFs function redundantly to regulate the development of embryos, cotyledons and leaves.
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    Genomic context

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    See CRF6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (22804998..22806527)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene POZ/BTB containin G-protein 1 Neighboring gene Galactose mutarotase-like superfamily protein Neighboring gene 3'-5'-exoribonuclease family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene arabinogalactan protein 20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytokinin response factor 6 negatively regulates leaf senescence and is induced in response to cytokinin and numerous abiotic stresses. Zwack PJ, et al. Plant Cell Physiol, 2013 Jun. PMID 23539244
    2. Cytokinin Response Factor 6 Represses Cytokinin-Associated Genes during Oxidative Stress. Zwack PJ, et al. Plant Physiol, 2016 Oct. PMID 27550996, Free PMC Article
    3. Cytokinin response factors regulate PIN-FORMED auxin transporters. Šimášková M, et al. Nat Commun, 2015 Nov 6. PMID 26541513
    4. A subset of Arabidopsis AP2 transcription factors mediates cytokinin responses in concert with a two-component pathway. Rashotte AM, et al. Proc Natl Acad Sci U S A, 2006 Jul 18. PMID 16832061, Free PMC Article
    5. CRFs form protein-protein interactions with each other and with members of the cytokinin signalling pathway in Arabidopsis via the CRF domain. Cutcliffe JW, et al. J Exp Bot, 2011 Oct. PMID 21705390, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that cytokinin response factor 6 (CRF6) functions during oxidative stress as a negative regulator to control this cytokinin-associated module of CRF6-dependent genes and establishes a novel connection between cytokinin and oxidative stress response.
      Title: Cytokinin Response Factor 6 Represses Cytokinin-Associated Genes during Oxidative Stress.
    2. CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development via transcriptional regulation of PIN-FORMED auxin transporters.
      Title: Cytokinin response factors regulate PIN-FORMED auxin transporters.
    3. CRF6 functions to regulate developmental senescence negatively and may have a similar role in response to stress.
      Title: Cytokinin response factor 6 negatively regulates leaf senescence and is induced in response to cytokinin and numerous abiotic stresses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_116028.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cotyledon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytokinin response factor 6
    NP_191722.1
    • cytokinin response factor 6 (CRF6); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: cytokinin response factor 5 (TAIR:AT2G46310.1); Has 5693 Blast hits to 5625 proteins in 245 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 5682; Viruses - 2; Other Eukaryotes - 9 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22804998..22806527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116028.4 → NP_191722.1  cytokinin response factor 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M374
      UniProtKB/TrEMBL
      A0A178VFH2, A0A5S9XPK5, A0A654FJW2
      Conserved Domains (1) summary
      smart00380
      Location:104 → 160
      AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M374.1

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