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    LHT1 lysine histidine transporter 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834078, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LHT1
    Official Full Name
    lysine histidine transporter 1
    Primary source
    TAIR:AT5G40780
    Locus tag
    AT5G40780
    See related
    Araport:AT5G40780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K1B16.3; K1B16_3; LYSINE AND HISTIDINE SPECIFIC TRANSPORTER; lysine histidine transporter 1
    Summary
    Encodes LHT1 (lysine histidine transporter), a high-affinity transporter for cellular amino acid uptake in both root epidermis and leaf mesophyll.
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    Genomic context

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    See LHT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (16323567..16327382)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene glucose-6-phosphate dehydrogenase 6 Neighboring gene prohibitin 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtLHT1 Transporter Can Facilitate the Uptake and Translocation of a Glycinergic-Chlorantraniliprole Conjugate in Arabidopsis thaliana. Chen Y, et al. J Agric Food Chem, 2018 Nov 28. PMID 30403859
    2. Amino acid transporter mutants of Arabidopsis provides evidence that a non-mycorrhizal plant acquires organic nitrogen from agricultural soil. Ganeteg U, et al. Plant Cell Environ, 2017 Mar. PMID 27943312
    3. Genetic identification of ACC-RESISTANT2 reveals involvement of LYSINE HISTIDINE TRANSPORTER1 in the uptake of 1-aminocyclopropane-1-carboxylic acid in Arabidopsis thaliana. Shin K, et al. Plant Cell Physiol, 2015 Mar. PMID 25520403
    4. Arabidopsis LHT1 is a high-affinity transporter for cellular amino acid uptake in both root epidermis and leaf mesophyll. Hirner A, et al. Plant Cell, 2006 Aug. PMID 16816136, Free PMC Article
    5. Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity. Yoo H, et al. Mol Plant, 2020 Jan 6. PMID 31568832, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Seedlings deficient in LHT1 exhibited a reduction with respect to both the uptake and root-to-shoot transfer of chlorantraniliprole-glycine conjugate
      Title: AtLHT1 Transporter Can Facilitate the Uptake and Translocation of a Glycinergic-Chlorantraniliprole Conjugate in Arabidopsis thaliana.
    2. LHT1 expression is crucial for plant uptake of organic Nitrogen from soil.
      Title: Amino acid transporter mutants of Arabidopsis provides evidence that a non-mycorrhizal plant acquires organic nitrogen from agricultural soil.
    3. A class of amino acid transporters including LHT1 takes part in transport of 1-Aminocyclopropane-1-carboxylic acid (ACC), thereby influencing exogenous ACC-induced ethylene responses in A. thaliana.[LHT1]
      Title: Genetic identification of ACC-RESISTANT2 reveals involvement of LYSINE HISTIDINE TRANSPORTER1 in the uptake of 1-aminocyclopropane-1-carboxylic acid in Arabidopsis thaliana.
    4. Map-based cloning of ARE2 demonstrated that LYSINE HISTIDINE TRANSPORTER1 (LHT1), encoding an amino acid transporter, is the gene responsible.
      Title: Genetic identification of ACC-RESISTANT2 reveals involvement of LYSINE HISTIDINE TRANSPORTER1 in the uptake of 1-aminocyclopropane-1-carboxylic acid in Arabidopsis thaliana.
    5. LHT1 functions in the uptake of amino acids in roots and the supply of leaf mesophyll with xylem-derived amino acids.
      Title: Arabidopsis LHT1 is a high-affinity transporter for cellular amino acid uptake in both root epidermis and leaf mesophyll.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001344353.1
    NM_001344354.1
    NM_180778.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    lysine histidine transporter 1
    NP_001318716.1
    • lysine histidine transporter 1; FUNCTIONS IN: amino acid transmembrane transporter activity; INVOLVED IN: amino acid transport, response to karrikin, amino acid import; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: Transmembrane amino acid transporter family protein (TAIR:AT1G48640.1); Has 4130 Blast hits to 4123 proteins in 343 species: Archae - 7; Bacteria - 195; Metazoa - 1180; Fungi - 628; Plants - 1642; Viruses - 0; Other Eukaryotes - 478 (source: NCBI BLink).
    NP_851109.1
    • lysine histidine transporter 1 (LHT1); FUNCTIONS IN: amino acid transmembrane transporter activity; INVOLVED IN: amino acid transport, response to karrikin, amino acid import; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Amino acid transporter, transmembrane (InterPro:IPR013057); BEST Arabidopsis thaliana protein match is: Transmembrane amino acid transporter family protein (TAIR:AT1G48640.1); Has 4138 Blast hits to 4131 proteins in 350 species: Archae - 7; Bacteria - 208; Metazoa - 1178; Fungi - 615; Plants - 1652; Viruses - 0; Other Eukaryotes - 478 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16323567..16327382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180778.4 → NP_851109.1  lysine histidine transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24405, Q3E8J8, Q9FKS8
      UniProtKB/TrEMBL
      A0A178UE12, A0A178UFA7, A0A5S9Y9Z4
      Conserved Domains (1) summary
      pfam01490
      Location:34 → 430
      Aa_trans; Transmembrane amino acid transporter protein

    2. NM_001344353.1 → NP_001318716.1  lysine histidine transporter 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UFA7, A0A1R7T3D5

    3. NM_001344354.1 → NP_001332682.1  lysine histidine transporter 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UFA7, A0A1R7T3D5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FKS8.1

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