RRS1 Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RRS1
Official Full Name: Disease resistance protein (TIR-NBS-LRR class)
Primary source: TAIR:AT5G45260
Locus tag: AT5G45260
See related: Araport:AT5G45260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA WRKY DOMAIN PROTEIN 52; ATWRKY52; K9E15.2; K9E15_2; RESISTANT TO RALSTONIA SOLANACEARUM 1; SENSITIVE TO LOW HUMIDITY 1; SLH1
Summary: Confers resistance to Ralstonia solanacearum. Similar to NBLS-TIR resistance genes,and also contains similarity to transcription factors. Interacts with pathogen effector protein AvrPop2.
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Genomic context

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See RRS1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 7

Sequence:: Chromosome: 5; NC_003076.8 (18326203..18332920)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secondary-structure switch regulates the substrate binding of a YopJ family acetyltransferase.
Title: Secondary-structure switch regulates the substrate binding of a YopJ family acetyltransferase.
Phosphorylation-Regulated Activation of the Arabidopsis RRS1-R/RPS4 Immune Receptor Complex Reveals Two Distinct Effector Recognition Mechanisms.
Title: Phosphorylation-Regulated Activation of the Arabidopsis RRS1-R/RPS4 Immune Receptor Complex Reveals Two Distinct Effector Recognition Mechanisms.
results provide novel information about the mechanisms which, in turn, hold an NLR protein complex inactive and allow adequate activation in the presence of pathogens. [RRS1-R]
Title: Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1-R immune receptor.
RRS1 domains responsible for response to bacterial effectors from plant pathogens.
Title: Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors.
Although quantitative disease resistance (QDR) to Xanthomonas campestris is conferred by At5g22540 encoding for a protein of unknown function, QDR to XccCFBP6943 involves the well-known immune receptor pair RRS1/RPS4.
Title: Quantitative disease resistance to the bacterial pathogen Xanthomonas campestris involves an Arabidopsis immune receptor pair and a gene of unknown function.
The RRS1-leucine zipper motif is crucial for the regulation of the RPS4/RRS1 complex.
Title: Leucine zipper motif in RRS1 is crucial for the regulation of Arabidopsis dual resistance protein complex RPS4/RRS1.
Here, we report that dual R proteins, RRS1 and RPS4, from A. thaliana ecotype Wassilewskija confer resistance to bacterial wilt in transgenic Brassica crops.
Title: Arabidopsis dual resistance proteins, both RPS4 and RRS1, are required for resistance to bacterial wilt in transgenic Brassica crops.
The Arabidopsis RRS1-R nucleotide-binding, leucine-rich repeat (NB-LRR) protein carries a C-terminal WRKY DNA binding domain and forms a receptor complex with RPS4, another NB-LRR protein. This complex detects the bacterial effectors AvrRps4 or PopP2 and then activates defense.
Title: A Plant Immune Receptor Detects Pathogen Effectors that Target WRKY Transcription Factors.
We show that many sushi(slh1) mutants carry mutations in RPS4, suggesting that RPS4 acts downstream or in a complex with RRS1. Interestingly, several mutations were identified in a domain C-terminal to the RPS4 LRR domain
Title: The nuclear immune receptor RPS4 is required for RRS1SLH1-dependent constitutive defense activation in Arabidopsis thaliana.
properly function for pathogen resistance in two other Brassicaceae, Brassica rapa and B. napus, but also in two Solanaceae, Nicotiana benthamiana and tomato (Solanum lycopersicum)
Title: Breaking restricted taxonomic functionality by dual resistance genes.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001085246.2

Supported by ESTs:

NM_001344604.1

Supported by ESTs:

NM_123894.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Disease resistance protein (TIR-NBS-LRR class)

NP_001318742.1

RESISTANT TO RALSTONIA SOLANACEARUM 1 (RRS1); CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Toll-Interleukin receptor (InterPro:IPR000157), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) (TAIR:AT5G45050.1); Has 16609 Blast hits to 13056 proteins in 554 species: Archae - 2; Bacteria - 1945; Metazoa - 277; Fungi - 50; Plants - 13999; Viruses - 4; Other Eukaryotes - 332 (source: NCBI BLink).

NP_199339.2

RESISTANT TO RALSTONIA SOLANACEARUM 1 (RRS1); CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657), NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) (TAIR:AT5G45050.1); Has 19764 Blast hits to 15744 proteins in 620 species: Archae - 2; Bacteria - 1944; Metazoa - 284; Fungi - 50; Plants - 17133; Viruses - 4; Other Eukaryotes - 347 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

18326203..18332920

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123894.4 → NP_199339.2 Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199339.2

Status: REVIEWED

UniProtKB/Swiss-Prot

C4B7M5, P0DKH5

Conserved Domains (5) summary

smart00774
Location:1209 → 1267

WRKY; DNA binding domain

COG4886
Location:553 → 912

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:624 → 646

LRR_RI; leucine-rich repeat [structural motif]

pfam00931
Location:175 → 415

NB-ARC; NB-ARC domain

pfam07725
Location:577 → 596

LRR_3; Leucine Rich Repeat
NM_001344604.1 → NP_001318742.1 Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

C4B7M5
NM_001085246.2 → NP_001078715.1 Disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078715.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C4B7M5

Conserved Domains (3) summary

PLN03210
Location:17 → 882

PLN03210; Resistant to P. syringae 6; Provisional

sd00033
Location:624 → 646

LRR_RI; leucine-rich repeat [structural motif]

pfam07725
Location:577 → 596

LRR_3; Leucine Rich Repeat