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    HL HAL2-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835527, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HL
    Official Full Name
    HAL2-like protein
    Primary source
    TAIR:AT5G54390
    Locus tag
    AT5G54390
    See related
    Araport:AT5G54390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AHL; ATAHL; F24B18.1; F24B18_1; HAL2-like
    Summary
    Encodes a 3'-phosphoadenosine-5'-phosphate (PAP) phosphatase that is sensitive to physiological concentrations of Na+. It does not also act as inositol polyphosphate 1-phosphatases, which other members of the HAL2-like family do. It is proposed that AHL acts in concert with sulphotransferases to prevent both the toxicity of PAP on RNA processing enzymes as well as the product inhibition of PAP on sulphate conjugation.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (22085998..22088094)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene protein kinase family protein Neighboring gene ncRNA Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis HAL2-like gene family includes a novel sodium-sensitive phosphatase. Gil-Mascarell R, et al. Plant J, 1999 Feb. PMID 10205895
    2. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124819.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3'(2'),5'-bisphosphate nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables inositol bisphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    HAL2-like protein
    NP_200250.1
    • HAL2-like (HL); FUNCTIONS IN: 3'(2'),5'-bisphosphate nucleotidase activity, inositol or phosphatidylinositol phosphatase activity; INVOLVED IN: sulfur metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Inositol monophosphatase, conserved site (InterPro:IPR020550), Inositol monophosphatase (InterPro:IPR000760), 3(2),5 -bisphosphate nucleotidase HAL2 (InterPro:IPR006239), Inositol monophosphatase, metal-binding site (InterPro:IPR020583); BEST Arabidopsis thaliana protein match is: Inositol monophosphatase family protein (TAIR:AT5G63980.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22085998..22088094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124819.3 → NP_200250.1  HAL2-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200250.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48892, Q38945
      UniProtKB/TrEMBL
      A0A178UGZ7, A0A5S9YEH2, A0A654GBF0
      Conserved Domains (1) summary
      TIGR01330
      Location:5 → 373
      bisphos_HAL2; 3'(2'),5'-bisphosphate nucleotidase, HAL2 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38945.1

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