U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    VIP2 VIRE2 interacting protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836092, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    VIP2
    Official Full Name
    VIRE2 interacting protein 2
    Primary source
    TAIR:AT5G59710
    Locus tag
    AT5G59710
    See related
    Araport:AT5G59710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtVIP2; MTH12.8; MTH12_8; Negative on TATA less2b; NOT2b; VIRE2 interacting protein 2
    Summary
    Encodes a nuclear-localized NOT (negative on TATA-less) domain-containing protein that interacts with the Agrobacterium VirE2 protein and is required for Agrobacterium-mediated plant transformation. It likely facilitates T-DNA integration into plant chromosomes and may play a role as a transcriptional regulator.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See VIP2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (24057378..24062082)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Histone superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene heat shock protein 18.2 Neighboring gene ncRNA Neighboring gene exocyst subunit exo70 family protein H7

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Overexpression of VIRE2-INTERACTING PROTEIN2 in Arabidopsis regulates genes involved in Agrobacterium-mediated plant transformation and abiotic stresses. Raman V, et al. Sci Rep, 2019 Sep 18. PMID 31534160, Free PMC Article
    2. VirD5 is required for efficient Agrobacterium infection and interacts with Arabidopsis VIP2. Wang Y, et al. New Phytol, 2018 Jan. PMID 29084344
    3. Arabidopsis VIRE2 INTERACTING PROTEIN2 is required for Agrobacterium T-DNA integration in plants. Anand A, et al. Plant Cell, 2007 May. PMID 17496122, Free PMC Article
    4. NOT2 proteins promote polymerase II-dependent transcription and interact with multiple MicroRNA biogenesis factors in Arabidopsis. Wang L, et al. Plant Cell, 2013 Feb. PMID 23424246, Free PMC Article
    5. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of VIRE2-INTERACTING PROTEIN2 in Arabidopsis regulates genes involved in Agrobacterium-mediated plant transformation and abiotic stresses.
      Title: Overexpression of VIRE2-INTERACTING PROTEIN2 in Arabidopsis regulates genes involved in Agrobacterium-mediated plant transformation and abiotic stresses.
    2. This work demonstrates experimentally that VirD5 is required for efficient Agrobacterium infection and may promote this process by competitive interaction with Arabidopsis VIP2.
      Title: VirD5 is required for efficient Agrobacterium infection and interacts with Arabidopsis VIP2.
    3. At5g59710 protein promotes polymerase II-dependent transcription and interact with multiple MicroRNA biogenesis factors.
      Title: NOT2 proteins promote polymerase II-dependent transcription and interact with multiple MicroRNA biogenesis factors in Arabidopsis.
    4. VIP2 interaction with VIP1, a basic domain/leucine zipper motif-containing protein is required for nuclear import and integration of T-DNA.
      Title: Arabidopsis VIRE2 INTERACTING PROTEIN2 is required for Agrobacterium T-DNA integration in plants.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001345367.1
    NM_001345368.1
    NM_125363.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA integration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    VIRE2 interacting protein 2
    NP_568912.2
    • VIRE2 interacting protein 2 (VIP2); CONTAINS InterPro DOMAIN/s: NOT2/NOT3/NOT5 (InterPro:IPR007282); BEST Arabidopsis thaliana protein match is: NOT2 / NOT3 / NOT5 family (TAIR:AT1G07705.2); Has 3791 Blast hits to 3038 proteins in 463 species: Archae - 1; Bacteria - 1471; Metazoa - 837; Fungi - 516; Plants - 178; Viruses - 9; Other Eukaryotes - 779 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24057378..24062082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125363.3 → NP_568912.2  VIRE2 interacting protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568912.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GZ37, Q9FPW4
      UniProtKB/TrEMBL
      A0A178UA65, A0A5S9YFS7
      Conserved Domains (1) summary
      pfam04153
      Location:484 → 603
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    2. NM_001345367.1 → NP_001329954.1  VIRE2 interacting protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GZ37, Q9FPW4
      UniProtKB/TrEMBL
      A0A178UA65, A0A5S9YFS7
      Conserved Domains (1) summary
      pfam04153
      Location:484 → 603
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    3. NM_001345368.1 → NP_001329955.1  VIRE2 interacting protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B9E0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FPW4.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools