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    APP1 aminopeptidase P1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829829, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APP1
    Official Full Name
    aminopeptidase P1
    Primary source
    TAIR:AT4G36760
    Locus tag
    AT4G36760
    See related
    Araport:AT4G36760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aminopeptidase P1; AP22.64; AP22_64; ARABIDOPSIS THALIANA AMINOPEPTIDASE P1; ATAPP1
    Summary
    Arabidopsis aminopeptidase P1
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    Genomic context

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    See APP1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Sequence:
    Chromosome: 4; NC_003075.7 (17326537..17330383)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene homeobox protein 40 Neighboring gene Quinone reductase family protein Neighboring gene UDP-Glycosyltransferase superfamily protein Neighboring gene ncRNA Neighboring gene BES1/BZR1 homolog 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A P-Loop NTPase Regulates Quiescent Center Cell Division and Distal Stem Cell Identity through the Regulation of ROS Homeostasis in Arabidopsis Root. Yu Q, et al. PLoS Genet, 2016 Sep. PMID 27583367, Free PMC Article
    2. Identification, purification, and molecular cloning of N-1-naphthylphthalmic acid-binding plasma membrane-associated aminopeptidases from Arabidopsis. Murphy AS, et al. Plant Physiol, 2002 Mar. PMID 11891249, Free PMC Article
    3. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APP1 is expressed in the root apical meristem cell mitochondria, and its product is associated with ATP hydrolase activity. SHR and SCR are important downstream targets of APP1.
      Title: A P-Loop NTPase Regulates Quiescent Center Cell Division and Distal Stem Cell Identity through the Regulation of ROS Homeostasis in Arabidopsis Root.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001342416.1
    NM_001342417.1
    NM_119840.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables N-1-naphthylphthalamic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin polar transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminopeptidase P1
    NP_195394.4
    • aminopeptidase P1 (APP1); FUNCTIONS IN: aminopeptidase activity, N-1-naphthylphthalamic acid binding; INVOLVED IN: auxin polar transport; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site (InterPro:IPR001131), Peptidase M24, structural domain (InterPro:IPR000994), Creatinase (InterPro:IPR000587); BEST Arabidopsis thaliana protein match is: Metallopeptidase M24 family protein (TAIR:AT3G05350.1); Has 10398 Blast hits to 10335 proteins in 2401 species: Archae - 277; Bacteria - 6310; Metazoa - 362; Fungi - 246; Plants - 146; Viruses - 0; Other Eukaryotes - 3057 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17326537..17330383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119840.7 → NP_195394.4  aminopeptidase P1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195394.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JQH3, O23206, Q6Q8B7, Q8H1P6
      UniProtKB/TrEMBL
      A0A178V0C7, A0A5S9Y1G5
      Conserved Domains (4) summary
      cd01085
      Location:333 → 578
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:5 → 128
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:581 → 640
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:148 → 330
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    2. NM_001342416.1 → NP_001328936.1  aminopeptidase P1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B667

    3. NM_001342417.1 → NP_001328935.1  aminopeptidase P1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B665
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JQH3.1

    Gene LinkOut

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