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    ACS1 ACC synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825324, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACS1
    Official Full Name
    ACC synthase 1
    Primary source
    TAIR:AT3G61510
    Locus tag
    AT3G61510
    See related
    Araport:AT3G61510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 1; ACC synthase 1; ARABIDOPSIS THALIANA 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 1; AT-ACS1
    Summary
    Encodes a member of the 1-aminocyclopropane-1-carboxylate (ACC) synthase (S-adenosyl-L-methionine methylthioadenosine-lyase, EC 4.4.1.14) gene family. The gene is transcriptionally active but enzymatically inactive. The predicted amino-acid sequence of ACS1 is missing the highly conserved tripeptide, Thr-Asn-Pro (TNP), between Ile204 and Ser205. Introduction of TNP into ACS1 restores the ACS activity.
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    Genomic context

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    See ACS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (22763495..22766010, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene BPS1-like protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Phosphoenolpyruvate carboxylase family protein Neighboring gene alpha/beta-Hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The dependence of leaf senescence on the balance between 1-aminocyclopropane-1-carboxylate acid synthase 1 (ACS1)-catalysed ACC generation and nitric oxide-associated 1 (NOS1)-dependent NO accumulation in Arabidopsis. Lv SF, et al. Plant Biol (Stuttg), 2019 Jul. PMID 30734982
    2. Characterization of two members (ACS1 and ACS3) of the 1-aminocyclopropane-1-carboxylate synthase gene family of Arabidopsis thaliana. Liang X, et al. Gene, 1995 Dec 29. PMID 8566772
    3. Heterodimeric interactions among the 1-amino-cyclopropane-1-carboxylate synthase polypeptides encoded by the Arabidopsis gene family. Tsuchisaka A, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983000, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. activity corresponds to the onset of leaf senescence
      Title: The dependence of leaf senescence on the balance between 1-aminocyclopropane-1-carboxylate acid synthase 1 (ACS1)-catalysed ACC generation and nitric oxide-associated 1 (NOS1)-dependent NO accumulation in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_116016.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables 1-aminocyclopropane-1-carboxylate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in ethylene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ACC synthase 1
    NP_191710.1
    • ACC synthase 1 (ACS1); CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class I/classII (InterPro:IPR004839), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: 1-amino-cyclopropane-1-carboxylate synthase 2 (TAIR:AT1G01480.1); Has 22999 Blast hits to 22998 proteins in 2818 species: Archae - 808; Bacteria - 15898; Metazoa - 560; Fungi - 631; Plants - 1241; Viruses - 0; Other Eukaryotes - 3861 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22763495..22766010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116016.2 → NP_191710.1  ACC synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q06429, Q43368, Q9S9C6
      UniProtKB/TrEMBL
      A0A654FJS5
      Conserved Domains (3) summary
      cd00609
      Location:89 → 427
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PLN02994
      Location:3 → 154
      PLN02994; 1-aminocyclopropane-1-carboxylate synthase
      PLN02376
      Location:4 → 488
      PLN02376; 1-aminocyclopropane-1-carboxylate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06429.2

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