U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DAR2 DA1-related protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818570, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    DAR2
    Official Full Name
    DA1-related protein 2
    Primary source
    TAIR:AT2G39830
    Locus tag
    AT2G39830
    See related
    Araport:AT2G39830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DA1-related protein 2; LATERAL ROOT DEVELOPMENT 3; LRD3; T5I7.13; T5I7_13
    Summary
    Essential for early phloem development and function, and for root system development.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See DAR2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (16619743..16624150, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Integral membrane Yip1 family protein Neighboring gene ubiquitin-protein ligase Neighboring gene Translation initiation factor IF6 Neighboring gene type one serine/threonine protein phosphatase 4 Neighboring gene Subtilisin-like serine endopeptidase family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Control of root meristem size by DA1-RELATED PROTEIN2 in Arabidopsis. Peng Y, et al. Plant Physiol, 2013 Mar. PMID 23296689, Free PMC Article
    2. Arabidopsis Lateral Root Development 3 is essential for early phloem development and function, and hence for normal root system development. Ingram P, et al. Plant J, 2011 Nov. PMID 21749503
    3. DAR2 acts as an important node connecting cytokinin, auxin, SHY2 and PLT1/2 in root meristem size control. Peng Y, et al. Plant Signal Behav, 2013 Jun. PMID 23518585, Free PMC Article
    4. UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2. Vanhaeren H, et al. Elife, 2020 Mar 25. PMID 32209225, Free PMC Article
    5. The ubiquitin receptors DA1, DAR1, and DAR2 redundantly regulate endoreduplication by modulating the stability of TCP14/15 in Arabidopsis. Peng Y, et al. Plant Cell, 2015 Mar. PMID 25757472, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DA1, DAR1, and DAR2 physically interact with the transcription factors TCP14 and TCP15, which repress endoreduplication.
      Title: The ubiquitin receptors DA1, DAR1, and DAR2 redundantly regulate endoreduplication by modulating the stability of TCP14/15 in Arabidopsis.
    2. acts downstream of cytokinin and SHY2 but upstream of PLT1/2 to affect root meristem size
      Title: DAR2 acts as an important node connecting cytokinin, auxin, SHY2 and PLT1/2 in root meristem size control.
    3. DAR2 acts through the PLETHORA pathway to influence root stem cell niche activity and therefore control root meristem size.
      Title: Control of root meristem size by DA1-RELATED PROTEIN2 in Arabidopsis.
    4. LATERAL ROOT DEVELOPMENT 3 is expressed in the phloem. Mutants display reduced primary root growth, altered root system architecture, and altered phloem callose deposition.
      Title: Arabidopsis Lateral Root Development 3 is essential for early phloem development and function, and hence for normal root system development.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001336801.1
    NM_129542.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phloem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA endoreduplication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DA1-related protein 2
    NP_181513.3
    • DA1-related protein 2 (DAR2); FUNCTIONS IN: zinc ion binding; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, LIM-type (InterPro:IPR001781), Protein of unknown function DUF3633 (InterPro:IPR022087); BEST Arabidopsis thaliana protein match is: LIM domain-containing protein (TAIR:AT4G36860.1); Has 1539 Blast hits to 1276 proteins in 109 species: Archae - 0; Bacteria - 10; Metazoa - 1178; Fungi - 26; Plants - 170; Viruses - 0; Other Eukaryotes - 155 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16619743..16624150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336800.1 → NP_001324811.1  DA1-related protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B191, A0A7G2EGV1

    2. NM_001336799.1 → NP_001324813.1  DA1-related protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1D5, A0A7G2EGV1

    3. NM_129542.5 → NP_181513.3  DA1-related protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181513.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22291, Q0WSN2
      UniProtKB/TrEMBL
      A0A178VRQ9, A0A5S9X5N7, A0A7G2EGV1
      Conserved Domains (2) summary
      cd09396
      Location:162 → 214
      LIM_DA1; The Lim domain of DA1
      pfam12315
      Location:311 → 523
      DA1-like; Protein DA1

    4. NM_001336801.1 → NP_001324812.1  DA1-related protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1A8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WSN2.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools