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    APL Homeodomain-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844281, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APL
    Official Full Name
    Homeodomain-like superfamily protein
    Primary source
    TAIR:AT1G79430
    Locus tag
    AT1G79430
    See related
    Araport:AT1G79430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ALTERED PHLOEM DEVELOPMENT; T8K14.15; T8K14_15; WDY; WOODY
    Summary
    Encodes gene product that is required for several aspects of phloem development in the root: (1) the specific divisions organizing the phloem pole, (2) sieve element differentiation and (3) the expression of a companion-specific gene. Mutant has a defect in the organization of phloem poles in the root. apl seedlings have a short, determinate root with only occasional lateral branches.
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    Genomic context

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    See APL in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (29877228..29879279, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene organic cation/carnitine transporter5 Neighboring gene C-type mannose receptor (DUF620) Neighboring gene aldehyde dehydrogenase 5F1 Neighboring gene ALA-interacting subunit 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FE Controls the Transcription of Downstream Flowering Regulators Through Two Distinct Mechanisms in Leaf Phloem Companion Cells. Shibuta M, et al. Plant Cell Physiol, 2017 Nov 1. PMID 29036620
    2. APL regulates vascular tissue identity in Arabidopsis. Bonke M, et al. Nature, 2003 Nov 13. PMID 14614507
    3. FE, a phloem-specific Myb-related protein, promotes flowering through transcriptional activation of FLOWERING LOCUS T and FLOWERING LOCUS T INTERACTING PROTEIN 1. Abe M, et al. Plant J, 2015 Sep. PMID 26239308
    4. Plant development. Arabidopsis NAC45/86 direct sieve element morphogenesis culminating in enucleation. Furuta KM, et al. Science, 2014 Aug 22. PMID 25081480
    5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APL (FE protein) regulates the transcription of FT and florigen transporter genes in different manners in leaf phloem companion cells.
      Title: FE Controls the Transcription of Downstream Flowering Regulators Through Two Distinct Mechanisms in Leaf Phloem Companion Cells.
    2. The FE protein regulates the expression of FTIP1 involved in FT transport. FE protein promotes flowering through transcriptional activation of FT and Ftip1.
      Title: FE, a phloem-specific Myb-related protein, promotes flowering through transcriptional activation of FLOWERING LOCUS T and FLOWERING LOCUS T INTERACTING PROTEIN 1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106591.2
    NM_179574.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phloem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Homeodomain-like superfamily protein
    NP_565209.1
    • ALTERED PHLOEM DEVELOPMENT (APL); BEST Arabidopsis thaliana protein match is: Homeodomain-like superfamily protein (TAIR:AT3G12730.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_849905.1
    • ALTERED PHLOEM DEVELOPMENT (APL); CONTAINS InterPro DOMAIN/s: Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Myb-like DNA-binding domain, SHAQKYF class (InterPro:IPR006447), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: Homeodomain-like superfamily protein (TAIR:AT3G12730.1); Has 1662 Blast hits to 1649 proteins in 60 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 2; Plants - 1644; Viruses - 0; Other Eukaryotes - 16 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29877228..29879279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179574.3 → NP_849905.1  Homeodomain-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849905.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFC9, Q94AW3, Q9SAK5
      UniProtKB/TrEMBL
      A0A5S9WVS7, A0A654F195
      Conserved Domains (2) summary
      TIGR01557
      Location:34 → 90
      myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class
      pfam14379
      Location:130 → 169
      Myb_CC_LHEQLE; MYB-CC type transfactor, LHEQLE motif

    2. NM_106591.2 → NP_565209.1  Homeodomain-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565209.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WVS7
      Conserved Domains (2) summary
      pfam14379
      Location:65 → 102
      Myb_CC_LHEQLE; MYB-CC type transfactor, LHEQLE motif
      cl21498
      Location:2 → 25
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SAK5.2

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