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    KCS3 3-ketoacyl-CoA synthase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837286, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KCS3
    Official Full Name
    3-ketoacyl-CoA synthase 3
    Primary source
    TAIR:AT1G07720
    Locus tag
    AT1G07720
    See related
    Araport:AT1G07720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3-ketoacyl-CoA synthase 3; F24B9.18; F24B9_18
    Summary
    Encodes KCS3, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
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    Genomic context

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    See KCS3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (2390531..2392628, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NOT2 / NOT3 / NOT5 family Neighboring gene ncRNA Neighboring gene Ankyrin repeat family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene exocyst subunit exo70 family protein H6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An ancestral role for 3-KETOACYL-COA SYNTHASE3 as a negative regulator of plant cuticular wax synthesis. Huang H, et al. Plant Cell, 2023 May 29. PMID 36807983, Free PMC Article
    2. Fine-tuning the activities of β-KETOACYL-COA SYNTHASE 3 (KCS3) and KCS12 in Arabidopsis is essential for maintaining cuticle integrity. Huang H, et al. J Exp Bot, 2023 Nov 21. PMID 37615538
    3. Characterization of the closely related Arabidopsis thaliana β-ketoacyl-CoA synthases KCS3, KCS12 and KCS19. Zhang Z, et al. Plant J, 2024 Jul. PMID 38666591
    4. The VLCFA elongase gene family in Arabidopsis thaliana: phylogenetic analysis, 3D modelling and expression profiling. Joubès J, et al. Plant Mol Biol, 2008 Jul. PMID 18465198
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of the closely related Arabidopsis thaliana beta-ketoacyl-CoA synthases KCS3, KCS12 and KCS19.
      Title: Characterization of the closely related Arabidopsis thaliana β-ketoacyl-CoA synthases KCS3, KCS12 and KCS19.
    2. Fine-tuning the activities of beta-KETOACYL-COA SYNTHASE 3 (KCS3) and KCS12 in Arabidopsis is essential for maintaining cuticle integrity.
      Title: Fine-tuning the activities of β-KETOACYL-COA SYNTHASE 3 (KCS3) and KCS12 in Arabidopsis is essential for maintaining cuticle integrity.
    3. An ancestral role for 3-KETOACYL-COA SYNTHASE3 as a negative regulator of plant cuticular wax synthesis.
      Title: An ancestral role for 3-KETOACYL-COA SYNTHASE3 as a negative regulator of plant cuticular wax synthesis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_100646.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-ketoacyl-CoA synthase 3
    NP_172251.1
    • 3-ketoacyl-CoA synthase 3 (KCS3); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acyltransferase activity; INVOLVED IN: response to cold, response to light stimulus, response to osmotic stress; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase-like (InterPro:IPR016039), Very-long-chain 3-ketoacyl-CoA synthase (InterPro:IPR012392), 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal (InterPro:IPR013747), FAE1/Type III polyketide synthase-like protein (InterPro:IPR013601), Thiolase-like, subgroup (InterPro:IPR016038); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-CoA synthase 12 (TAIR:AT2G28630.1); Has 2897 Blast hits to 2863 proteins in 795 species: Archae - 0; Bacteria - 1421; Metazoa - 0; Fungi - 2; Plants - 1311; Viruses - 0; Other Eukaryotes - 163 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2390531..2392628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331724.1 → NP_001322003.1  3-ketoacyl-CoA synthase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AST0, A0A5S9T6V9, A0A7G2DR08

    2. NM_100646.3 → NP_172251.1  3-ketoacyl-CoA synthase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172251.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LQP8
      UniProtKB/TrEMBL
      A0A178W3A1, A0A5S9T6V9, A0A7G2DR08
      Conserved Domains (2) summary
      pfam08392
      Location:23 → 300
      FAE1_CUT1_RppA; FAE1/Type III polyketide synthase-like protein
      cl21486
      Location:334 → 424
      Ketoacyl-synt_C; Beta-ketoacyl synthase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LQP8.3

    Gene LinkOut

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