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    GER1 GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843659, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GER1
    Official Full Name
    GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase 1
    Primary source
    TAIR:AT1G73250
    Locus tag
    AT1G73250
    See related
    Araport:AT1G73250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''GDP-4-keto-6-deoxymannose-3; 5-EPIMERASE-4-REDUCTASE; 5-epimerase-4-reductase 1; 5-epimerase-4-reductase 1''; ACTIVATING TRANSCRIPTION FACTOR 5; ATFX; GDP-4-KETO-6-DEOXY-D-MANNOSE-3; GDP-4-keto-6-deoxymannose-3; T18K17.8; T18K17_8
    Summary
    encodes a bifunctional 3, 5-epimerase-4-reductase in L-fucose synthesis and converts GDP-D-mannose to GDP-L-fucose in vitro along with MUR1 (GDP-D-mannose 4,6-dehydratase). It is expressed in all tissues examined, but most abundantly in roots and flowers.
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    Genomic context

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    See GER1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (27544969..27546479, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene organic cation/carnitine transporter1 Neighboring gene Nascent polypeptide-associated complex NAC Neighboring gene nucleoporin protein Ndc1-Nup protein Neighboring gene kunitz trypsin inhibitor 1 Neighboring gene serine carboxypeptidase-like 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A bifunctional epimerase-reductase acts downstream of the MUR1 gene product and completes the de novo synthesis of GDP-L-fucose in Arabidopsis. Bonin CP, et al. Plant J, 2000 Mar. PMID 10758496
    2. Interaction of GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase with GDP-mannose-4,6-dehydratase stabilizes the enzyme activity for formation of GDP-fucose from GDP-mannose. Nakayama K, et al. Glycobiology, 2003 Oct. PMID 12881408
    3. Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID. Mair A, et al. Elife, 2019 Sep 19. PMID 31535972, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105984.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GDP-L-fucose synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GDP-L-fucose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in L-ascorbic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within L-fucose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase 1
    NP_177468.2
    • ''GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase 1'' (GER1); CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT1G17890.1); Has 26333 Blast hits to 26329 proteins in 2769 species: Archae - 655; Bacteria - 15410; Metazoa - 462; Fungi - 218; Plants - 758; Viruses - 25; Other Eukaryotes - 8805 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27544969..27546479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105984.4 → NP_177468.2  GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177468.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49213, Q0WQ67
      UniProtKB/TrEMBL
      A0A178WGY4, A0A5S9WTY1
      Conserved Domains (2) summary
      PLN02725
      Location:20 → 323
      PLN02725; GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase
      pfam01370
      Location:19 → 250
      Epimerase; NAD dependent epimerase/dehydratase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49213.3

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