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    LYK5 Protein kinase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817923, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LYK5
    Official Full Name
    Protein kinase superfamily protein
    Primary source
    TAIR:AT2G33580
    Locus tag
    AT2G33580
    See related
    Araport:AT2G33580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtLYK5; F4P9.35; F4P9_35; LysM-containing receptor-like kinase 5
    Summary
    Encodes a LysM-containing receptor-like kinase. LYK5 is a major chitin receptor and forms a chitin-induced complex with related kinase CERK1.
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    Genomic context

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    See LYK5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (14219481..14222254, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene BUB1-related (BUB1: budding uninhibited by benzymidazol 1) Neighboring gene glycosyltransferase family protein (DUF23) Neighboring gene subtilisin-like protease Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis E3 ubiquitin ligase PLANT U-BOX13 (PUB13) regulates chitin receptor LYSIN MOTIF RECEPTOR KINASE5 (LYK5) protein abundance. Liao D, et al. New Phytol, 2017 Jun. PMID 28195333
    2. The Arabidopsis thaliana LysM-containing Receptor-Like Kinase 2 is required for elicitor-induced resistance to pathogens. Giovannoni M, et al. Plant Cell Environ, 2021 Dec. PMID 34558681, Free PMC Article
    3. The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1. Cao Y, et al. Elife, 2014 Oct 23. PMID 25340959, Free PMC Article
    4. LYK4, a lysin motif receptor-like kinase, is important for chitin signaling and plant innate immunity in Arabidopsis. Wan J, et al. Plant Physiol, 2012 Sep. PMID 22744984, Free PMC Article
    5. A user-friendly platform for yeast two-hybrid library screening using next generation sequencing. Erffelinck ML, et al. PLoS One, 2018. PMID 30576311, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis thaliana LysM-containing Receptor-Like Kinase 2 is required for elicitor-induced resistance to pathogens.
      Title: The Arabidopsis thaliana LysM-containing Receptor-Like Kinase 2 is required for elicitor-induced resistance to pathogens.
    2. An important regulatory function for the turnover of LYK5 mediated by the E3 ligase PUB13.
      Title: Arabidopsis E3 ubiquitin ligase PLANT U-BOX13 (PUB13) regulates chitin receptor LYSIN MOTIF RECEPTOR KINASE5 (LYK5) protein abundance.
    3. AtLYK5 is the primary receptor for chitin, forming a chitin inducible complex with AtCERK1 to induce plant immunity. [LYK5]
      Title: The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128918.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables chitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to chitin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein kinase superfamily protein
    NP_180916.1
    • Protein kinase superfamily protein; FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation, cell wall macromolecule catabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidoglycan-binding lysin domain (InterPro:IPR018392), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: protein kinase family protein / peptidoglycan-binding LysM domain-containing protein (TAIR:AT2G23770.1); Has 102109 Blast hits to 101070 proteins in 4036 species: Archae - 73; Bacteria - 10993; Metazoa - 38718; Fungi - 7726; Plants - 30221; Viruses - 349; Other Eukaryotes - 14029 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14219481..14222254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128918.5 → NP_180916.1  Protein kinase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22808
      UniProtKB/TrEMBL
      A0A178VYW5, A0A5S9X3Q0, A0A654EYH8
      Conserved Domains (2) summary
      pfam01476
      Location:197 → 239
      LysM; LysM domain
      cl21453
      Location:380 → 640
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22808.1

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