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    ALMT12 aluminum-activated, malate transporter 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827522, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALMT12
    Official Full Name
    aluminum-activated, malate transporter 12
    Primary source
    TAIR:AT4G17970
    Locus tag
    AT4G17970
    See related
    Araport:AT4G17970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aluminum-activated; ATALMT12; malate transporter 12; QUAC1; quick-activating anion channel 1; T6K21.150; T6K21_150
    Summary
    Anion transporter involved in stomatal closure. Gene has 3 splicing variants.
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    Genomic context

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    See ALMT12 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (9975365..9978023)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene AT hook motif DNA-binding family protein Neighboring gene phospholipid hydroperoxide glutathione peroxidase Neighboring gene tRNA-Cys Neighboring gene NAC domain containing protein 71

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drought-Enhanced Xylem Sap Sulfate Closes Stomata by Affecting ALMT12 and Guard Cell ABA Synthesis. Malcheska F, et al. Plant Physiol, 2017 Jun. PMID 28446637, Free PMC Article
    2. Enhanced Photosynthesis and Growth in atquac1 Knockout Mutants Are Due to Altered Organic Acid Accumulation and an Increase in Both Stomatal and Mesophyll Conductance. Medeiros DB, et al. Plant Physiol, 2016 Jan. PMID 26542441, Free PMC Article
    3. C-terminus-mediated voltage gating of Arabidopsis guard cell anion channel QUAC1. Mumm P, et al. Mol Plant, 2013 Sep. PMID 23314055
    4. AtALMT12 represents an R-type anion channel required for stomatal movement in Arabidopsis guard cells. Meyer S, et al. Plant J, 2010 Sep. PMID 20626656
    5. Closing plant stomata requires a homolog of an aluminum-activated malate transporter. Sasaki T, et al. Plant Cell Physiol, 2010 Mar. PMID 20154005, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ALMT12 role in drought induced stomatal closure
      Title: Drought-Enhanced Xylem Sap Sulfate Closes Stomata by Affecting ALMT12 and Guard Cell ABA Synthesis.
    2. QUAC1, an R-type anion channel responsible for the release of malate from guard cells, is essential for efficient stomatal closure and plays a role in mesophyll conductance.
      Title: Enhanced Photosynthesis and Growth in atquac1 Knockout Mutants Are Due to Altered Organic Acid Accumulation and an Increase in Both Stomatal and Mesophyll Conductance.
    3. In the presence of abscissic acid, OST1 is able to phosphorylate/activate the plant anion channels QUAC1 and SLAC1, leading to stomatal closure.[QUAC1]
      Title: Open stomata 1 (OST1) kinase controls R-type anion channel QUAC1 in Arabidopsis guard cells.
    4. The cytosolic C-terminus is involved in the voltage-dependent gating mechanism of QUAC1.
      Title: C-terminus-mediated voltage gating of Arabidopsis guard cell anion channel QUAC1.
    5. Activity of heterologously expressed AtALMT12 depends on extracellular malate. Thereby this key metabolite and osmolite of guard cells shifts the threshold for voltage activation of AtALMT12 towards more hyperpolarized potentials.
      Title: AtALMT12 represents an R-type anion channel required for stomatal movement in Arabidopsis guard cells.
    6. AtALMT12 is a novel class of anion transporter involved in stomatal closure.
      Title: Closing plant stomata requires a homolog of an aluminum-activated malate transporter.
    Submit: New GeneRIF Correction

    General gene information

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    NM_117907.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables monoatomic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in malate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aluminum-activated, malate transporter 12
    NP_193531.1
    • ''aluminum-activated, malate transporter 12'' (ALMT12); CONTAINS InterPro DOMAIN/s: Malate transporter, aliminium toerance (InterPro:IPR020966); BEST Arabidopsis thaliana protein match is: Aluminium activated malate transporter family protein (TAIR:AT5G46610.1); Has 747 Blast hits to 732 proteins in 202 species: Archae - 0; Bacteria - 352; Metazoa - 0; Fungi - 13; Plants - 354; Viruses - 0; Other Eukaryotes - 28 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9975365..9978023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117907.4 → NP_193531.1  aluminum-activated, malate transporter 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193531.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49696
      UniProtKB/TrEMBL
      A0A178UYB4
      Conserved Domains (1) summary
      pfam11744
      Location:38 → 525
      ALMT; Aluminium activated malate transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49696.1

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