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    ADS1 MATE efflux family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829035, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADS1
    Official Full Name
    MATE efflux family protein
    Primary source
    TAIR:AT4G29140
    Locus tag
    AT4G29140
    See related
    Araport:AT4G29140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACTIVATED DISEASE SUSCEPTIBILITY 1; ADP1; ALTERED DEVELOPMENT PROGRAM 1; F19B15.170; F19B15_170
    Summary
    Encodes Activated Disease Susceptibility 1 (ADS1), a putative MATE (multidrug and toxic compound extrusion) transport protein that negatively regulates plant disease resistance.
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    Genomic context

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    See ADS1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (14368877..14371195)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene IQ-domain 25 Neighboring gene SNF7 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Noncanonical ATG8-ABS3 interaction controls senescence in plants. Jia M, et al. Nat Plants, 2019 Feb. PMID 30664732, Free PMC Article
    2. ADP1 affects abundance and endocytosis of PIN-FORMED proteins in Arabidopsis. Li J, et al. Plant Signal Behav, 2015. PMID 25482774, Free PMC Article
    3. ADP1 affects plant architecture by regulating local auxin biosynthesis. Li R, et al. PLoS Genet, 2014 Jan. PMID 24391508, Free PMC Article
    4. ADS1 encodes a MATE-transporter that negatively regulates plant disease resistance. Sun X, et al. New Phytol, 2011 Oct. PMID 21762165
    5. A subgroup of MATE transporter genes regulates hypocotyl cell elongation in Arabidopsis. Wang R, et al. J Exp Bot, 2015 Oct. PMID 26160579

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATG8-ABS3(AT4G29140) interaction is required for ABS3-mediated senescence.ATG8-ABS3 interaction is uncoupled from ABS3 transporter activity or the autophagic function of ATG8.
      Title: Noncanonical ATG8-ABS3 interaction controls senescence in plants.
    2. It was concluded that ADP1 regulates plant architecture through the fine-tuning of local auxin biosynthesis and through post-transcriptional regulation of auxin transporters.
      Title: ADP1 affects abundance and endocytosis of PIN-FORMED proteins in Arabidopsis.
    3. ADP1-mediated regulation of the local auxin level in meristematic regions is an essential determinant for plant architecture maintenance by restraining the outgrowth of lateral organs. [ADP1]
      Title: ADP1 affects plant architecture by regulating local auxin biosynthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_119058.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of auxin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in root morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MATE efflux family protein
    NP_194643.1
    • MATE efflux family protein; FUNCTIONS IN: antiporter activity, drug transmembrane transporter activity, transporter activity; INVOLVED IN: drug transmembrane transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: shoot apex, embryo, hypocotyl, root; EXPRESSED DURING: E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT5G19700.1); Has 10278 Blast hits to 10238 proteins in 1962 species: Archae - 240; Bacteria - 7294; Metazoa - 150; Fungi - 320; Plants - 1306; Viruses - 0; Other Eukaryotes - 968 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14368877..14371195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119058.3 → NP_194643.1  MATE efflux family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194643.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SZE2
      UniProtKB/TrEMBL
      A0A178UVA9, A0A5S9XX97
      Conserved Domains (1) summary
      cd13132
      Location:56 → 492
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SZE2.1

    Gene LinkOut

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