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    VLN3 villin 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824908, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VLN3
    Official Full Name
    villin 3
    Primary source
    TAIR:AT3G57410
    Locus tag
    AT3G57410
    See related
    Araport:AT3G57410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATVLN3; F28O9.1; villin 3
    Summary
    Encodes a protein with high homology to animal villin. VLN3 is a Ca2+-regulated villin involved in actin filament bundling.
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    Genomic context

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    See VLN3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    26
    Sequence:
    Chromosome: 3; NC_003074.8 (21243136..21251159, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transmembrane protein, putative (DUF288) Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis VILLIN2 and VILLIN3 act redundantly in sclerenchyma development via bundling of actin filaments. Bao C, et al. Plant J, 2012 Sep. PMID 22563899
    2. Arabidopsis VILLIN2 and VILLIN3 are required for the generation of thick actin filament bundles and for directional organ growth. van der Honing HS, et al. Plant Physiol, 2012 Mar. PMID 22209875, Free PMC Article
    3. Arabidopsis VILLIN1 and VILLIN3 have overlapping and distinct activities in actin bundle formation and turnover. Khurana P, et al. Plant Cell, 2010 Aug. PMID 20807878, Free PMC Article
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VLN2 and VLN3 act redundantly in sclerenchyma development via bundling of actin filaments.
      Title: Arabidopsis VILLIN2 and VILLIN3 act redundantly in sclerenchyma development via bundling of actin filaments.
    2. The headpiece region of VLN3 is required for the bundling of actin filaments.
      Title: Arabidopsis VILLIN2 and VILLIN3 are required for the generation of thick actin filament bundles and for directional organ growth.
    3. VLN3 binds to and bundles F-Actin in a Ca2+-insensitive manner. It severs actin filaments in a Ca2+-dependent manner.
      Title: Arabidopsis VILLIN1 and VILLIN3 have overlapping and distinct activities in actin bundle formation and turnover.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001339858.1
    NM_001339859.1
    NM_001339860.1
    NM_001339862.1
    NM_001339864.1
    NM_001339865.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament bundle assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament severing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    villin 3
    NP_001319779.1
    • villin 3 (VLN3); FUNCTIONS IN: actin binding; INVOLVED IN: cytoskeleton organization; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Gelsolin (InterPro:IPR007122), Villin headpiece (InterPro:IPR003128), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: villin 2 (TAIR:AT2G41740.1); Has 7542 Blast hits to 2948 proteins in 413 species: Archae - 0; Bacteria - 496; Metazoa - 2427; Fungi - 350; Plants - 307; Viruses - 25; Other Eukaryotes - 3937 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21243136..21251159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115601.3 → NP_567048.1  villin 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLW4, C0Z212, O81645, Q9LEA4, Q9SCN1
      UniProtKB/TrEMBL
      A0A5S9XLM7, A0A654FIM5
      Conserved Domains (7) summary
      smart00153
      Location:930 → 965
      VHP; Villin headpiece domain
      cd11288
      Location:519 → 609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:139 → 232
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:12 → 124
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:622 → 720
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:254 → 343
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:386 → 487
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    2. NM_001339861.1 → NP_001325651.1  villin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLW4, C0Z212, O81645, Q9LEA4, Q9SCN1
      UniProtKB/TrEMBL
      A0A5S9XLM7, A0A654FIM5

    3. NM_001339863.1 → NP_001325647.1  villin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLW4, C0Z212, O81645, Q9LEA4, Q9SCN1
      UniProtKB/TrEMBL
      A0A5S9XLM7, A0A654FIM5

    4. NM_001339866.1 → NP_001325646.1  villin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLW4, C0Z212, O81645, Q9LEA4, Q9SCN1
      UniProtKB/TrEMBL
      A0A5S9XLM7, A0A654FIM5

    5. NM_001339858.1 → NP_001319779.1  villin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLW4, C0Z212, O81645, Q9LEA4, Q9SCN1
      UniProtKB/TrEMBL
      A0A5S9XLM7, A0A654FIM5

    6. NM_001339862.1 → NP_001325648.1  villin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLW4, C0Z212, O81645, Q9LEA4, Q9SCN1
      UniProtKB/TrEMBL
      A0A5S9XLM7, A0A654FIM5

    7. NM_001339865.1 → NP_001325649.1  villin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLW4, C0Z212, O81645, Q9LEA4, Q9SCN1
      UniProtKB/TrEMBL
      A0A5S9XLM7, A0A654FIM5

    8. NM_001339860.1 → NP_001325645.1  villin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LLW4, C0Z212, O81645, Q9LEA4, Q9SCN1
      UniProtKB/TrEMBL
      A0A5S9XLM7, A0A654FIM5

    9. NM_001339864.1 → NP_001325650.1  villin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VFR4, A0A1I9LLW3

    10. NM_001339859.1 → NP_001325644.1  villin 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LLV6, Q8RWJ0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81645.2

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