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    CPL2 carboxyl-terminal domain (ctd) phosphatase-like 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831743, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPL2
    Official Full Name
    carboxyl-terminal domain (ctd) phosphatase-like 2
    Primary source
    TAIR:AT5G01270
    Locus tag
    AT5G01270
    See related
    Araport:AT5G01270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCPL2; carboxyl-terminal domain (ctd) phosphatase-like 2; F7J8.250; F7J8_250
    Summary
    Encodes CPL2, a carboxyl-terminal domain (CTD) phosphatase that dephosphorylates CTD Ser5-PO4 of the RNA polymerase II complex. Regulates plant growth, stress and auxin responses.
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    Genomic context

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    See CPL2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (107547..112324, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene alpha 1,4-glycosyltransferase family protein Neighboring gene Carbohydrate-binding-like fold Neighboring gene GPI-anchored protein Neighboring gene mRNA capping enzyme family protein Neighboring gene PEBP (phosphatidylethanolamine-binding protein) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CPL2 and CPL3 act redundantly in FLC activation and flowering time regulation in Arabidopsis. Zhang Y, et al. Plant Signal Behav, 2022 Dec 31. PMID 35112651, Free PMC Article
    2. The Arabidopsis thaliana carboxyl-terminal domain phosphatase-like 2 regulates plant growth, stress and auxin responses. Ueda A, et al. Plant Mol Biol, 2008 Aug. PMID 18506580
    3. KH domain protein RCF3 is a tissue-biased regulator of the plant miRNA biogenesis cofactor HYL1. Karlsson P, et al. Proc Natl Acad Sci U S A, 2015 Nov 10. PMID 26512101, Free PMC Article
    4. Arabidopsis C-terminal domain phosphatase-like 1 and 2 are essential Ser-5-specific C-terminal domain phosphatases. Koiwa H, et al. Proc Natl Acad Sci U S A, 2004 Oct 5. PMID 15388846, Free PMC Article
    5. Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis. Zhang YZ, et al. Nat Commun, 2020 Dec 4. PMID 33277495, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis plants that express CPL2 mutants exhibited leaf expansion defects, early flowering, low fertility, and increased salt sensitivity.
      Title: The Arabidopsis thaliana carboxyl-terminal domain phosphatase-like 2 regulates plant growth, stress and auxin responses.
    2. The mechanisms of reading the CTD code by two classes of protein phosphatases, plant CPLs and yeast Ssu72, that specifically dephosphorylate Ser(5) in vitro are reported.
      Title: Different strategies for carboxyl-terminal domain (CTD) recognition by serine 5-specific CTD phosphatases.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001203270.1
    NM_120205.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in auxin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression, epigenetic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of photoperiodism, flowering IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within_negative_effect regulation of photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    carboxyl-terminal domain (ctd) phosphatase-like 2
    NP_001190199.1
    • carboxyl-terminal domain (ctd) phosphatase-like 2 (CPL2); FUNCTIONS IN: double-stranded RNA binding, phosphatase activity; INVOLVED IN: response to auxin stimulus, response to osmotic stress, developmental growth; LOCATED IN: intracellular; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Double-stranded RNA-binding (InterPro:IPR001159), Double-stranded RNA-binding-like (InterPro:IPR014720), NLI interacting factor (InterPro:IPR004274); BEST Arabidopsis thaliana protein match is: C-terminal domain phosphatase-like 1 (TAIR:AT4G21670.1).
    NP_195747.2
    • carboxyl-terminal domain (ctd) phosphatase-like 2 (CPL2); FUNCTIONS IN: double-stranded RNA binding, phosphatase activity; INVOLVED IN: response to auxin stimulus, response to osmotic stress, developmental growth; LOCATED IN: intracellular; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Double-stranded RNA-binding (InterPro:IPR001159), Double-stranded RNA-binding-like (InterPro:IPR014720), NLI interacting factor (InterPro:IPR004274); BEST Arabidopsis thaliana protein match is: C-terminal domain phosphatase-like 1 (TAIR:AT4G21670.1); Has 234 Blast hits to 223 proteins in 82 species: Archae - 0; Bacteria - 8; Metazoa - 40; Fungi - 61; Plants - 110; Viruses - 0; Other Eukaryotes - 15 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      107547..112324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120205.5 → NP_195747.2  carboxyl-terminal domain (ctd) phosphatase-like 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195747.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K803, Q5YDB5, Q9LFA9
      UniProtKB/TrEMBL
      A0A178UG98, A0A7G2F9J5
      Conserved Domains (3) summary
      PHA03247
      Location:461 → 654
      PHA03247; large tegument protein UL36; Provisional
      cd07521
      Location:244 → 355
      HAD_FCP1-like; human CTD phosphatase subunit 1 (CTDP1/FCP1) and related proteins; belongs to the haloacid dehalogenase-like superfamily
      cd10845
      Location:657 → 720
      DSRM_RNAse_III_family; double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins

    2. NM_001203270.1 → NP_001190199.1  carboxyl-terminal domain (ctd) phosphatase-like 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F9J5, F4K802
      Conserved Domains (2) summary
      pfam00035
      Location:658 → 720
      dsrm; Double-stranded RNA binding motif
      cl21460
      Location:255 → 348
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5YDB5.3

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