HOS15 WD-40 repeat family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HOS15
Official Full Name: WD-40 repeat family protein
Primary source: TAIR:AT5G67320
Locus tag: AT5G67320
See related: Araport:AT5G67320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: high expression of osmotically responsive genes 15; K8K14.4; K8K14_4
Summary: Encodes a WD-40 protein involved in histone deacetylation in response to abiotic stress.Identified in a screen for mutations with altered expression of stress induced genes. Functions as a repressor of cold tolerance induced genes. Loss of function mutants are hypersensitive to freezing.
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Genomic context

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See HOS15 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 14

Sequence:: Chromosome: 5; NC_003076.8 (26857154..26861119)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis.
Title: HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis.
HOS15-PWR chromatin remodeling complex positively regulates cold stress in Arabidopsis.
Title: HOS15-PWR chromatin remodeling complex positively regulates cold stress in Arabidopsis.
HOS15 and HDA9 negatively regulate immunity through histone deacetylation of intracellular immune receptor NLR genes in Arabidopsis.
Title: HOS15 and HDA9 negatively regulate immunity through histone deacetylation of intracellular immune receptor NLR genes in Arabidopsis.
HOS15: A missing link that fine-tunes ABA signaling and drought tolerance in Arabidopsis.
Title: HOS15: A missing link that fine-tunes ABA signaling and drought tolerance in Arabidopsis.
Rheostatic Control of ABA Signaling through HOS15-Mediated OST1 Degradation
Title: Rheostatic Control of ABA Signaling through HOS15-Mediated OST1 Degradation.
HOS15 forms a core complex with HDA9 and PWR to control gene expression and plant development.
Title: HDA9-PWR-HOS15 Is a Core Histone Deacetylase Complex Regulating Transcription and Development.
The identification and functional characterization of HOS15, a WD40-repeat protein crucial for repression of genes associated with abiotic stress tolerance through histone deacetylation in Arabidopsis, is reported. [HOS15]
Title: Involvement of Arabidopsis HOS15 in histone deacetylation and cold tolerance.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_126132.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: WD-40 repeat family protein

NP_201533.1

high expression of osmotically responsive genes 15 (HOS15); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), LisH dimerisation motif, subgroup (InterPro:IPR013720), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: TBP-associated factor 5 (TAIR:AT5G25150.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

26857154..26861119

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126132.4 → NP_201533.1 WD-40 repeat family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_201533.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q56Y40, Q9FN19

UniProtKB/TrEMBL

A0A178UQT7, A0A5S9YIJ7, A0A7G2FNB3

Conserved Domains (3) summary

cd00200
Location:258 → 569

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:327 → 363

7WD40; WD40 repeat [structural motif]

pfam08513
Location:8 → 32

LisH