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    IWS1 Transcription elongation factor (TFIIS) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840105, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IWS1
    Official Full Name
    Transcription elongation factor (TFIIS) family protein
    Primary source
    TAIR:AT1G32130
    Locus tag
    AT1G32130
    See related
    Araport:AT1G32130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA IWS1 (FROM YEAST INTERACTS WITH SPT6); ATIWS1; F3C3.8; F3C3_8; HIGH NITROGEN INSENSITIVE 9; HNI9
    Summary
    The C-terminal portion of this protein has high homology to the C-termini of the IWS1 (Interacts With Spt6) proteins found in yeast and humans. Interacts with transcription factor BES1. Involved in brassinosteroid-regulated gene expression.
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    Genomic context

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    See IWS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (11558755..11561920, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein phosphatase 7 long form-like protein Neighboring gene plant viral-response family protein Neighboring gene F-box family protein Neighboring gene basic region/leucine zipper transcription factor 68

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High nitrogen insensitive 9 (HNI9)-mediated systemic repression of root NO3- uptake is associated with changes in histone methylation. Widiez T, et al. Proc Natl Acad Sci U S A, 2011 Aug 9. PMID 21788519, Free PMC Article
    2. The Chromatin Factor HNI9 and ELONGATED HYPOCOTYL5 Maintain ROS Homeostasis under High Nitrogen Provision. Bellegarde F, et al. Plant Physiol, 2019 May. PMID 30824566, Free PMC Article
    3. Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana. Wang X, et al. Mol Plant, 2014 Aug. PMID 24838002
    4. Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression. Li L, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20139304, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HNI9 is required to up-regulate the expression of genes involved in redox processes in response to high nitrogen provision.
      Title: The Chromatin Factor HNI9 and ELONGATED HYPOCOTYL5 Maintain ROS Homeostasis under High Nitrogen Provision.
    2. HNI9 encodes Arabidopsis INTERACT WITH SPT6 (AtIWS1), an evolutionary conserved component of the RNA polymerase II complex.[HNI9]
      Title: High nitrogen insensitive 9 (HNI9)-mediated systemic repression of root NO3- uptake is associated with changes in histone methylation.
    3. AtIWS1 is recruited to target genes by BES1 to promote gene expression during transcription elongation process.
      Title: Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198197.1
    NM_102946.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brassinosteroid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within brassinosteroid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription elongation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Transcription elongation factor (TFIIS) family protein
    NP_001185126.1
    • IWS1; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: brassinosteroid mediated signaling pathway, regulation of RNA elongation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor IIS, N-terminal (InterPro:IPR017923); BEST Arabidopsis thaliana protein match is: Transcription elongation factor (TFIIS) family protein (TAIR:AT4G19000.1).
    NP_174492.2
    • IWS1; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: brassinosteroid mediated signaling pathway, regulation of RNA elongation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor IIS, N-terminal (InterPro:IPR017923); BEST Arabidopsis thaliana protein match is: Transcription elongation factor (TFIIS) family protein (TAIR:AT4G19000.1); Has 1384 Blast hits to 1350 proteins in 337 species: Archae - 10; Bacteria - 21; Metazoa - 458; Fungi - 242; Plants - 332; Viruses - 8; Other Eukaryotes - 313 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11558755..11561920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102946.4 → NP_174492.2  Transcription elongation factor (TFIIS) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174492.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4ICK8, Q9FVQ8
      UniProtKB/TrEMBL
      A0A178W8Z5, A0A5S9WKQ6
      Conserved Domains (1) summary
      cl00146
      Location:61 → 475
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

    2. NM_001198197.1 → NP_001185126.1  Transcription elongation factor (TFIIS) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WKQ6, F4ICK7
      Conserved Domains (1) summary
      cl00146
      Location:61 → 474
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4ICK8.1

    Gene LinkOut

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